ent-Kaurene Glycosides from Ageratina cylindrica

ent-Kaurene Glycosides from Ageratina cylindrica

The aqueous extract of the leaves of Ageratina cylindrica afforded six new ent-kaurenoic acid glycosides together with the known diterpenoid paniculoside V, the flavonoid astragalin, chlorogenic acid, and l-chiro-inositol. The structures were elucidated mainly by NMR and MS methods, and the absolute...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2015-11, Vol.78 (11), p.2580-2587
Hauptverfasser: Bustos-Brito, Celia, Sánchez-Castellanos, Mariano, Esquivel, Baldomero, Calderón, José S, Calzada, Fernando, Yépez-Mulia, Lilian, Joseph-Nathan, Pedro, Cuevas, Gabriel, Quijano, Leovigildo
Format: Artikel
Sprache:eng
Schlagworte:
Ageratina - chemistry
Animals
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Circular Dichroism
Diterpenes
Diterpenes, Kaurane - chemistry
Diterpenes, Kaurane - isolation & purification
Diterpenes, Kaurane - pharmacology
Entamoeba histolytica - drug effects
Giardia lamblia - drug effects
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Kaempferols - chemistry
Kaempferols - isolation & purification
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Parasitic Sensitivity Tests
Plant Leaves - drug effects
Trophozoites - drug effects
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Beschreibung
Zusammenfassung:The aqueous extract of the leaves of Ageratina cylindrica afforded six new ent-kaurenoic acid glycosides together with the known diterpenoid paniculoside V, the flavonoid astragalin, chlorogenic acid, and l-chiro-inositol. The structures were elucidated mainly by NMR and MS methods, and the absolute configuration was established by vibrational circular dichroism spectroscopy. The new compounds showed moderate antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.5b00488