The Gut-Lung Axis in Respiratory Disease
Host-microorganism interactions shape local cell functionality, immune responses, and can influence disease development. Evidence indicates that the impact of host-microbe interactions reaches far beyond the local environment, thus influencing responses in peripheral tissues. There is a vital cross-...
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| Veröffentlicht in: | Annals of the American Thoracic Society 2015-11, Vol.12 Suppl 2 (Supplement 2), p.S150-S156 |
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| container_end_page | S156 |
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| container_issue | Supplement 2 |
| container_start_page | S150 |
| container_title | Annals of the American Thoracic Society |
| container_volume | 12 Suppl 2 |
| creator | Marsland, Benjamin J Trompette, Aurélien Gollwitzer, Eva S |
| description | Host-microorganism interactions shape local cell functionality, immune responses, and can influence disease development. Evidence indicates that the impact of host-microbe interactions reaches far beyond the local environment, thus influencing responses in peripheral tissues. There is a vital cross-talk between the mucosal tissues of our body, as exemplified by intestinal complications during respiratory disease and vice versa. Although, mechanistically, this phenomenon remains poorly defined, the existence of the gut-lung axis and its implications in both health and disease could be profoundly important for both disease etiology and treatment. In this review, we highlight how changes in the intestinal microenvironment, with a particular focus on the intestinal microbiota, impact upon respiratory disease. |
| doi_str_mv | 10.1513/AnnalsATS.201503-133AW |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 2329-6933 |
| ispartof | Annals of the American Thoracic Society, 2015-11, Vol.12 Suppl 2 (Supplement 2), p.S150-S156 |
| issn | 2329-6933 2325-6621 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1736415489 |
| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Host-Pathogen Interactions Humans Intestinal Mucosa - microbiology Microbiota Probiotics - therapeutic use Respiratory Mucosa - microbiology Respiratory Tract Diseases - drug therapy Respiratory Tract Diseases - microbiology |
| title | The Gut-Lung Axis in Respiratory Disease |
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