Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages

Krüppel-like factor 4 (KLF4) is a critical regulator of monocyte differentiation and macrophage polarization, and it also plays an important role in several vascular diseases, including atherosclerosis. Apolipoprotein E (apoE) is an essential anti-atherosclerotic glycoprotein involved in lipid metab...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-12, Vol.468 (1-2), p.66-72
Hauptverfasser:	Stavri, Simona, Simionescu, Maya, Kardassis, Dimitris, Gafencu, Anca V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein E Apolipoproteins E - genetics Base Sequence Cell Differentiation Cell Line CREB Cyclic AMP Response Element-Binding Protein - metabolism Gene regulation Humans KLF4 Kruppel-Like Transcription Factors - metabolism Macrophage Macrophages - cytology Macrophages - metabolism Molecular Sequence Data Monocyte differentiation Monocytes - cytology Monocytes - metabolism Promoter Regions, Genetic Up-Regulation
Online-Zugang:	Volltext
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