Ensembling and filtering: an effective and rapid in silico multitarget drug-design strategy to identify RIPK1 and RIPK3 inhibitors

Necroptosis, a programmed necrosis pathway, is witnessed in diverse human diseases and is primarily regulated by receptor-interacting serine/threonine protein kinase 1 (RIPK1) and RIPK3. Ablation or inhibition of these individual proteins, or both, has been shown to be protective in various in vitro...

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Veröffentlicht in:	Journal of molecular modeling 2015-12, Vol.21 (12), p.314-314, Article 314
Hauptverfasser:	Fayaz, S. M., Rajanikant, G. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Computer Appl. in Life Sciences Computer Applications in Chemistry Drug Design Humans Ligands Molecular Dynamics Simulation Molecular Medicine Original Paper Protein Kinase Inhibitors - chemistry Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors Receptor-Interacting Protein Serine-Threonine Kinases - chemistry Theoretical and Computational Chemistry
Online-Zugang:	Volltext
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