Increased levels of adenosine and ecto 5′-nucleotidase (CD73) activity precede renal alterations in experimental diabetic rats

The pathogenesis of diabetic nephropathy (DN) has not been clearly established, making diagnosis and patient management difficult. Recent studies using experimental diabetic models have implicated adenosine signaling with renal cells dysfunction. Therefore, the study of the biochemical mechanisms th...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-12, Vol.468 (1-2), p.354-359
Hauptverfasser:	Oyarzún, C., Salinas, C., Gómez, D., Jaramillo, K., Pérez, G., Alarcón, S., Podestá, L., Flores, C., Quezada, C., San Martín, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - analysis 5'-Nucleotidase - metabolism 5'-Nucleotidase - urine 5’-ectonucleotidase Adenosine Adenosine - analysis Adenosine - metabolism Adenosine - urine Adenosine Monophosphate - metabolism Animals Cell Line Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - urine Diabetic Nephropathies - complications Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - urine Diabetic nephropathy Humans Kidney - metabolism Kidney - pathology Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Male Rats Rats, Sprague-Dawley Urinary biomarkers
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