Vinpocetine blockade of sodium channels inhibits the rise in sodium and calcium induced by 4-aminopyridine in synaptosomes

The objective of this study was to get a more understandable picture of the mechanism underlying the anticonvulsant action of vinpocetine. The question of how the cerebral excitability is affected was investigated by determining the effect of vinpocetine on the changes on the internal concentrations...

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Veröffentlicht in:	Neurochemistry international 2005-06, Vol.46 (7), p.533-540
Hauptverfasser:	Sitges, María, Galván, Emilio, Nekrassov, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Animals Anticonvulsant Anticonvulsants - pharmacology Biological and medical sciences Calcium - metabolism Calcium channels Calcium Channels - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Male Neostriatum - chemistry Potassium Channel Blockers - pharmacology Rats Rats, Wistar Sodium - metabolism Sodium Channel Blockers - pharmacology Sodium channels Sodium Channels - drug effects Sodium Channels - metabolism Synapses - chemistry Synapses - drug effects Synapses - metabolism Synaptic Membranes - drug effects Synaptic Membranes - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptosomes Synaptosomes - chemistry Synaptosomes - drug effects Synaptosomes - metabolism Tetrodotoxin Tetrodotoxin - pharmacology Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: nervous system and sense organs Vinca Alkaloids - pharmacology
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