Mechanistic Implications from Crystalline Complexes of Wild-Type and Mutant Adenylosuccinate Synthetases from Escherichia coli

Asp13 and His41 are essential residues of adenylosuccinate synthetase, putatively catalyzing the formation of adenylosuccinate from an intermediate of 6-phosphoryl-IMP. Wild-type adenylosuccinate synthetase and three mutant synthetases (Arg143 → Leu, Lys16 → Gln, and Arg303 → Leu) from Eschericha co...

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Veröffentlicht in:	Biochemistry (Easton) 1999-05, Vol.38 (21), p.6953-6961
Hauptverfasser:	Choe, Jun-Yong, Poland, Bradley W, Fromm, Herbert J, Honzatko, Richard B
Format:	Artikel
Sprache:	eng
Schlagworte:	adenylosuccinate synthase Adenylosuccinate Synthase - chemistry Adenylosuccinate Synthase - genetics Adenylosuccinate Synthase - metabolism Aspartic Acid - chemistry Aspartic Acid - metabolism Binding Sites - genetics Crystallization Crystallography, X-Ray Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Guanosine Diphosphate - chemistry Guanosine Diphosphate - metabolism Guanosine Triphosphate - chemistry Guanosine Triphosphate - metabolism Hydrogen Bonding Inosine Monophosphate - chemistry Inosine Monophosphate - metabolism Magnesium - chemistry Magnesium - metabolism Models, Molecular Mutagenesis, Site-Directed
Online-Zugang:	Volltext
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