Complexes of DNA with the Antimicrobial Peptide LL37 Augment NK Cell Functions by Inducing Type I Interferon Production from Circulating Monocytes and Plasmacytoid Predendritic Cells

The cationic antimicrobial peptide, LL37, forms electrostatic complexes with DNA (LL37-DNA), which are potent activators of circulating plasmacytoid predendritic cells (ppDCs) and monocytes. However, the effects of LL37-DNA on other immune cell types, such as NK cells, are poorly characterized. In t...

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Veröffentlicht in:	Journal of interferon & cytokine research 2015-11, Vol.35 (11), p.850-858
Hauptverfasser:	Pinegin, Boris V, Pashenkov, Mikhail V, Kulakov, Vladimir V, Murugin, Vladimir V, Zhmak, Maxim N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimicrobial Cationic Peptides Cathelicidins - metabolism Cell Degranulation - immunology Cells, Cultured Dendritic Cells - immunology DNA - metabolism Enzyme-Linked Immunosorbent Assay Humans Interferon Type I - biosynthesis Interferon Type I - immunology Interferon-gamma - biosynthesis Interferon-gamma - immunology Killer Cells, Natural - immunology Leukocytes, Mononuclear - immunology Lymphocyte Activation - immunology Middle Aged Neoplasms - immunology Real-Time Polymerase Chain Reaction Young Adult
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