Purine metabolism gene deregulation in Parkinson's disease

Aims To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. Methods Analysis of mR...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2015-12, Vol.41 (7), p.926-940
Hauptverfasser:	Garcia-Esparcia, Paula, Hernández-Ortega, Karina, Ansoleaga, Belén, Carmona, Margarita, Ferrer, Isidre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Astrocytes - metabolism Astrocytes - pathology Drosophila Enzymes Female frontal cortex Frontal Lobe - metabolism Frontal Lobe - pathology Gene Expression Regulation Genes Humans Male Metabolism Microglia - metabolism Microglia - pathology Middle Aged Neurons - metabolism Neurons - pathology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease purine metabolism enzymes Purines - metabolism putamen Putamen - metabolism Putamen - pathology substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology
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