Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks

•ω-Agatoxin inhibits activity more readily in spinal cord cultures than frontal cortex.•Cluster analysis detected two unit specific responses for frontal cortex networks.•Addition of bicuculline, a GABAA inhibitor, isolated a single response to ω-agatoxin.•ω-Agatoxin decreases activity by blocking e...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2013-07, Vol.37, p.19-25
Hauptverfasser:	Knaack, Gretchen L., Charkhkar, Hamid, Hamilton, Franz W., Peixoto, Nathalia, O'Shaughnessy, Thomas J., Pancrazio, Joseph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biological and medical sciences Calcium Channel Blockers - toxicity Calcium Channels, P-Type - drug effects Calcium Channels, P-Type - metabolism Calcium Channels, Q-Type - drug effects Calcium Channels, Q-Type - metabolism Calcium Signaling - drug effects Cells, Cultured Dose-Response Relationship, Drug Extracellular recordings Frontal Lobe - drug effects Frontal Lobe - metabolism Frontal Lobe - pathology GABA-A Receptor Antagonists - pharmacology Medical sciences Mice Microelectrode array Nerve Net - drug effects Nerve Net - metabolism Nerve Net - pathology Neural Inhibition - drug effects omega-Agatoxin IVA - toxicity Primary neuronal cultures Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Toxicology ω-Agatoxin-IVA
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