Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human Na sub(v)1.1 Mutation

Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable networks are largely unknown. Here, we present a multisystem analysis of an SCN1A mouse model carrying the Na sub(v)1.1-R1648H mutation, wh...

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Veröffentlicht in:	The Journal of neuroscience 2014-01, Vol.34 (45), p.14874-14889
Hauptverfasser:	Hedrich, Ulrike BS, Liautard, Camille, Kirschenbaum, Daniel, Pofahl, Martin, Lavigne, Jennifer, Liu, Yuanyuan, Theiss, Stephan, Slotta, Johannes, Escayg, Andrew, Dihne, Marcel, Beck, Heinz, Mantegazza, Massimo, Lerche, Holger
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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