Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome

Abstract Promiscuous gene expression (pGE) of tissue-restricted self-antigens (TRA) in medullary thymic epithelial cells (mTECs) is in part driven by the Autoimmune Regulator gene ( AIRE ) and essential for self-tolerance. The link between AIRE functional mutations and multi-organ autoimmunity in hu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of autoimmunity 2015-06, Vol.60, p.12-19
Hauptverfasser:	Alvarez, Iñaki, Collado, Javier A, Colobran, Roger, Carrascal, Montserrat, Ciudad, M. Teresa, Canals, Françesc, James, Eddie A, Kwok, William W, Gärtner, Martina, Kyewski, Bruno, Pujol-Borrell, Ricardo, Jaraquemada, Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over AIRE Protein Allergy and Immunology Animals Autoantigens Autoantigens - biosynthesis Autoantigens - immunology Autoimmunity - immunology Child Child, Preschool Contactin 2 - biosynthesis Contactin 2 - immunology Epithelial Cells - immunology Female Gene Expression Profiling HLA-DR Antigens - immunology Human Humans Infant Infant, Newborn Male MHC Mice Middle Aged Peptides Self Tolerance - immunology Seminal Vesicle Secretory Proteins - biosynthesis Seminal Vesicle Secretory Proteins - immunology T-Lymphocytes - immunology Thymus Thymus Gland - cytology Thymus Gland - immunology Tolerance Transcription Factors - biosynthesis Transcriptome Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!