Indirect phosphorylation-dependent modulation of postsynaptic nicotinic acetylcholine responses by 5-hydroxytryptamine

Ionotropic nicotinic acetylcholine (ACh) receptors have been shown to be modulated by protein kinase‐mediated phosphorylation in vitro. Here we demonstrate that 5‐hydroxytryptamine (5‐HT) can downregulate postsynaptic nicotinic ACh responses, elicited in an identified arthropod motoneuron in situ, b...

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Veröffentlicht in:	The European journal of neuroscience 2005-03, Vol.21 (5), p.1181-1188
Hauptverfasser:	Butt, S. J. B., Pitman, R. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology ACh Animals Central Nervous System - cytology Central Nervous System - drug effects Cockroaches Cyclic AMP - pharmacology Cyclic GMP - pharmacology cyclic nucleotide Drug Interactions Electric Stimulation - methods Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology In Vitro Techniques Male Membrane Potentials - drug effects Membrane Potentials - radiation effects Motor Neurons - drug effects Motor Neurons - radiation effects Patch-Clamp Techniques - methods Phosphorylation - drug effects protein kinase Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism serotonin Serotonin - pharmacology Staurosporine - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - radiation effects Theophylline - pharmacology Time Factors
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