Inorganic mercury pre-exposures protect against methyl mercury toxicity in NSC-34 (neuron×spinal cord hybrid) cells

A neuron spinal chord × hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0–16 μM) resulted in significant dose-dependent cell damage and death ( P

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Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 1999-02, Vol.132 (2), p.167-178
Hauptverfasser:	Chapman, Laurie Ann, Chan, Hing Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Animals Biological and medical sciences Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Cultured neurons glutathione Glutathione - analysis Hybrid Cells Inorganic mercury Medical sciences mercuric chloride Mercury - pharmacology Metallothionein Metallothionein - analysis Metals and various inorganic compounds Methyl mercury Methylmercury Compounds - toxicity Mice Neurons - drug effects Neurotoxicity Spinal Cord - drug effects Toxicology Zinc Zinc - pharmacology
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Beschreibung
Zusammenfassung:	A neuron spinal chord × hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0–16 μM) resulted in significant dose-dependent cell damage and death ( P
ISSN:	0300-483X 1879-3185
DOI:	10.1016/S0300-483X(98)00151-6