Controlled release of copper from an intrauterine device using a biodegradable polymer
Abstract Background The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. Study desi...
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| Veröffentlicht in: | Contraception (Stoneham) 2015-12, Vol.92 (6), p.585-588 |
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| creator | Ramakrishnan, Reshmi B, Bharaniraja Aprem, Abi Santhosh |
| description | Abstract Background The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. Study design This study evaluated in vitro release rates of copper for a period of 1 year from standard CuT380 IUDs ( n = 6) and from CuT380 IUDs coated with poly( dl -lactide-co-glycolide) (PLGA) films ( n = 6). This study characterized the coated device for its morphological changes during degradation of film by scanning electron microscopy (SEM). Results CuT380 IUDs coated with PLGA film with a thickness of 0.10±0.02 mm showed a reduced initial copper release (40–80 mcg/day) compared with uncoated CuT380 IUDs (150–200 mcg/day). Statistically significant (p |
| doi_str_mv | 10.1016/j.contraception.2015.08.014 |
| format | Article |
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This study focuses on controlling the initial burst release of copper ions. Study design This study evaluated in vitro release rates of copper for a period of 1 year from standard CuT380 IUDs ( n = 6) and from CuT380 IUDs coated with poly( dl -lactide-co-glycolide) (PLGA) films ( n = 6). This study characterized the coated device for its morphological changes during degradation of film by scanning electron microscopy (SEM). Results CuT380 IUDs coated with PLGA film with a thickness of 0.10±0.02 mm showed a reduced initial copper release (40–80 mcg/day) compared with uncoated CuT380 IUDs (150–200 mcg/day). Statistically significant (p<.05) results were obtained at different time intervals during the overall study period of 1 year. SEM images showed degradation of coating. Conclusion Coating a CuT380 IUD with biodegradable polymer reduced the initial copper release without affecting release at 1 year. Clinical trials are required to determine whether this could reduce side effects such as bleeding and pain associated with copper containing IUDs.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2015.08.014</identifier><identifier>PMID: 26363430</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biodegradable polymer ; Controlled release ; Copper - analysis ; Copper intrauterine device ; Equipment Design - methods ; Female ; Humans ; Intrauterine Devices, Copper - adverse effects ; Microscopy, Electron, Scanning ; Obstetrics and Gynecology ; PLGA ; Polyglactin 910 - therapeutic use ; Polymers - metabolism ; Trace Elements - analysis</subject><ispartof>Contraception (Stoneham), 2015-12, Vol.92 (6), p.585-588</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-8df9d51431e179349673ed09a924cc8f9d728ef11f9368d213e8b6dd652e69083</citedby><cites>FETCH-LOGICAL-c491t-8df9d51431e179349673ed09a924cc8f9d728ef11f9368d213e8b6dd652e69083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.contraception.2015.08.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26363430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramakrishnan, Reshmi</creatorcontrib><creatorcontrib>B, Bharaniraja</creatorcontrib><creatorcontrib>Aprem, Abi Santhosh</creatorcontrib><title>Controlled release of copper from an intrauterine device using a biodegradable polymer</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Background The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. Study design This study evaluated in vitro release rates of copper for a period of 1 year from standard CuT380 IUDs ( n = 6) and from CuT380 IUDs coated with poly( dl -lactide-co-glycolide) (PLGA) films ( n = 6). This study characterized the coated device for its morphological changes during degradation of film by scanning electron microscopy (SEM). Results CuT380 IUDs coated with PLGA film with a thickness of 0.10±0.02 mm showed a reduced initial copper release (40–80 mcg/day) compared with uncoated CuT380 IUDs (150–200 mcg/day). Statistically significant (p<.05) results were obtained at different time intervals during the overall study period of 1 year. SEM images showed degradation of coating. Conclusion Coating a CuT380 IUD with biodegradable polymer reduced the initial copper release without affecting release at 1 year. Clinical trials are required to determine whether this could reduce side effects such as bleeding and pain associated with copper containing IUDs.</description><subject>Biodegradable polymer</subject><subject>Controlled release</subject><subject>Copper - analysis</subject><subject>Copper intrauterine device</subject><subject>Equipment Design - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Intrauterine Devices, Copper - adverse effects</subject><subject>Microscopy, Electron, Scanning</subject><subject>Obstetrics and Gynecology</subject><subject>PLGA</subject><subject>Polyglactin 910 - therapeutic use</subject><subject>Polymers - metabolism</subject><subject>Trace Elements - analysis</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEQx4Mo7rj6FSTgxUu3VUk_0giCDLursODBxzVkkuolY7rTJt0L8-23m1kFPXmqQ_0f1K8Ye4NQImDz7ljaOM7JWJpmH8dSANYlqBKwesJ2qNqugBrVU7YDQChaJaoL9iLnIwC0Xd0-ZxeikY2sJOzYj_2WFUMgxxMFMpl47LmN00SJ9ykO3Izcb33LTMmPxB3de0t8yX6844YffHR0l4wzh0B8iuE0UHrJnvUmZHr1OC_Z9-urb_tPxe2Xm8_7j7eFrTqcC-X6ztVYSSRsO1l1TSvJQWc6UVmr1mUrFPWIfScb5QRKUofGuaYW1HSg5CV7e86dUvy1UJ714LOlEMxIcckaW1lLKRDFKn1_ltoUc07U6yn5waSTRtAbWH3Uf4HVG1gNSq9gV_frx6LlMJD74_1NchVcnQW0nnvvKelsPY2WnE9kZ-2i_8-iD__k2OBHb034SSfKx7ikcSWqUWehQX_dfry9GGuAugUpHwCKqabH</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Ramakrishnan, Reshmi</creator><creator>B, Bharaniraja</creator><creator>Aprem, Abi Santhosh</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Controlled release of copper from an intrauterine device using a biodegradable polymer</title><author>Ramakrishnan, Reshmi ; B, Bharaniraja ; Aprem, Abi Santhosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-8df9d51431e179349673ed09a924cc8f9d728ef11f9368d213e8b6dd652e69083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biodegradable polymer</topic><topic>Controlled release</topic><topic>Copper - analysis</topic><topic>Copper intrauterine device</topic><topic>Equipment Design - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Intrauterine Devices, Copper - adverse effects</topic><topic>Microscopy, Electron, Scanning</topic><topic>Obstetrics and Gynecology</topic><topic>PLGA</topic><topic>Polyglactin 910 - therapeutic use</topic><topic>Polymers - metabolism</topic><topic>Trace Elements - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramakrishnan, Reshmi</creatorcontrib><creatorcontrib>B, Bharaniraja</creatorcontrib><creatorcontrib>Aprem, Abi Santhosh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramakrishnan, Reshmi</au><au>B, Bharaniraja</au><au>Aprem, Abi Santhosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of copper from an intrauterine device using a biodegradable polymer</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>92</volume><issue>6</issue><spage>585</spage><epage>588</epage><pages>585-588</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><abstract>Abstract Background The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. Study design This study evaluated in vitro release rates of copper for a period of 1 year from standard CuT380 IUDs ( n = 6) and from CuT380 IUDs coated with poly( dl -lactide-co-glycolide) (PLGA) films ( n = 6). This study characterized the coated device for its morphological changes during degradation of film by scanning electron microscopy (SEM). Results CuT380 IUDs coated with PLGA film with a thickness of 0.10±0.02 mm showed a reduced initial copper release (40–80 mcg/day) compared with uncoated CuT380 IUDs (150–200 mcg/day). Statistically significant (p<.05) results were obtained at different time intervals during the overall study period of 1 year. SEM images showed degradation of coating. Conclusion Coating a CuT380 IUD with biodegradable polymer reduced the initial copper release without affecting release at 1 year. Clinical trials are required to determine whether this could reduce side effects such as bleeding and pain associated with copper containing IUDs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26363430</pmid><doi>10.1016/j.contraception.2015.08.014</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biodegradable polymer Controlled release Copper - analysis Copper intrauterine device Equipment Design - methods Female Humans Intrauterine Devices, Copper - adverse effects Microscopy, Electron, Scanning Obstetrics and Gynecology PLGA Polyglactin 910 - therapeutic use Polymers - metabolism Trace Elements - analysis |
| title | Controlled release of copper from an intrauterine device using a biodegradable polymer |
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