Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy
Background Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with isc...
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| Veröffentlicht in: | Clinical research in cardiology 2015-12, Vol.104 (12), p.1072-1077 |
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| creator | Kosiuk, Jedrzej Dinov, Borislav Bollmann, Andreas Koutalas, Emmanuel Mussigbrodt, Andreas Sommer, Phillipp Arya, Arash Richter, Sergio Hindricks, Gerhard Breithardt, Ole A. |
| description | Background
Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied.
Methods and results
In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15–58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms,
p
= 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63–1.00,
p
= 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1–143.4,
p
= 0.024).
Conclusions
In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF. |
| doi_str_mv | 10.1007/s00392-015-0875-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1735331419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3872441561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-313fc9ca43f7d236d630e89204aac324c3eedaca2d97e472b8bfdf588b29b26a3</originalsourceid><addsrcrecordid>eNp1kcuKFTEQhoMozjj6AG4k4MZNa259yXIYvMGAG12H6qTaztCdPqa6HfpNfFxz5oyDCEIgRfLVVwk_Yy-leCuFaN-RENqqSsi6El1bV-0jdi67RlaiserxQ92ZM_aM6EaIWgptnrIz1QhV11ads1-XRIuPsMYl8R7XW8TEf2Jac_TbBJlDzuO-jnME4pACn_fFQw4RJj6jHyFFX8oQ6YCZjhIgwrIC73dOa4ZYjhJMO0XipT6UUUVP_DauI09LiuRHnKPnd9ql-Asy7s_ZkwEmwhf3-wX79uH916tP1fWXj5-vLq8rb4xaKy314K0Ho4c2KN2ERgvsrBIGwGtlvEYM4EEF26JpVd_1QxjqruuV7VUD-oK9OXkPefmxIa1uLi_CaYKEy0ZOtrrWWhppC_r6H_Rm2XL52x1lbFP8olDyRPm8EGUc3CHHGfLupHDH2NwpNldic8fYXFt6Xt2bt37G8NDxJ6cCqBNA5Sp9x_zX6P9afwMfDqea</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1734964720</pqid></control><display><type>article</type><title>Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kosiuk, Jedrzej ; Dinov, Borislav ; Bollmann, Andreas ; Koutalas, Emmanuel ; Mussigbrodt, Andreas ; Sommer, Phillipp ; Arya, Arash ; Richter, Sergio ; Hindricks, Gerhard ; Breithardt, Ole A.</creator><creatorcontrib>Kosiuk, Jedrzej ; Dinov, Borislav ; Bollmann, Andreas ; Koutalas, Emmanuel ; Mussigbrodt, Andreas ; Sommer, Phillipp ; Arya, Arash ; Richter, Sergio ; Hindricks, Gerhard ; Breithardt, Ole A.</creatorcontrib><description>Background
Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied.
Methods and results
In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15–58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms,
p
= 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63–1.00,
p
= 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1–143.4,
p
= 0.024).
Conclusions
In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.</description><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s00392-015-0875-7</identifier><identifier>PMID: 26025592</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cardiology ; Cardiomyopathies - physiopathology ; Echocardiography - methods ; Female ; Humans ; Incidence ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Paper ; Risk ; Tachycardia, Ventricular - epidemiology ; Tachycardia, Ventricular - physiopathology ; Time Factors ; Ventricular Fibrillation - epidemiology ; Ventricular Fibrillation - physiopathology</subject><ispartof>Clinical research in cardiology, 2015-12, Vol.104 (12), p.1072-1077</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-313fc9ca43f7d236d630e89204aac324c3eedaca2d97e472b8bfdf588b29b26a3</citedby><cites>FETCH-LOGICAL-c442t-313fc9ca43f7d236d630e89204aac324c3eedaca2d97e472b8bfdf588b29b26a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00392-015-0875-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00392-015-0875-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26025592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kosiuk, Jedrzej</creatorcontrib><creatorcontrib>Dinov, Borislav</creatorcontrib><creatorcontrib>Bollmann, Andreas</creatorcontrib><creatorcontrib>Koutalas, Emmanuel</creatorcontrib><creatorcontrib>Mussigbrodt, Andreas</creatorcontrib><creatorcontrib>Sommer, Phillipp</creatorcontrib><creatorcontrib>Arya, Arash</creatorcontrib><creatorcontrib>Richter, Sergio</creatorcontrib><creatorcontrib>Hindricks, Gerhard</creatorcontrib><creatorcontrib>Breithardt, Ole A.</creatorcontrib><title>Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy</title><title>Clinical research in cardiology</title><addtitle>Clin Res Cardiol</addtitle><addtitle>Clin Res Cardiol</addtitle><description>Background
Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied.
Methods and results
In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15–58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms,
p
= 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63–1.00,
p
= 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1–143.4,
p
= 0.024).
Conclusions
In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.</description><subject>Aged</subject><subject>Cardiology</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Risk</subject><subject>Tachycardia, Ventricular - epidemiology</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>Time Factors</subject><subject>Ventricular Fibrillation - epidemiology</subject><subject>Ventricular Fibrillation - physiopathology</subject><issn>1861-0684</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcuKFTEQhoMozjj6AG4k4MZNa259yXIYvMGAG12H6qTaztCdPqa6HfpNfFxz5oyDCEIgRfLVVwk_Yy-leCuFaN-RENqqSsi6El1bV-0jdi67RlaiserxQ92ZM_aM6EaIWgptnrIz1QhV11ads1-XRIuPsMYl8R7XW8TEf2Jac_TbBJlDzuO-jnME4pACn_fFQw4RJj6jHyFFX8oQ6YCZjhIgwrIC73dOa4ZYjhJMO0XipT6UUUVP_DauI09LiuRHnKPnd9ql-Asy7s_ZkwEmwhf3-wX79uH916tP1fWXj5-vLq8rb4xaKy314K0Ho4c2KN2ERgvsrBIGwGtlvEYM4EEF26JpVd_1QxjqruuV7VUD-oK9OXkPefmxIa1uLi_CaYKEy0ZOtrrWWhppC_r6H_Rm2XL52x1lbFP8olDyRPm8EGUc3CHHGfLupHDH2NwpNldic8fYXFt6Xt2bt37G8NDxJ6cCqBNA5Sp9x_zX6P9afwMfDqea</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Kosiuk, Jedrzej</creator><creator>Dinov, Borislav</creator><creator>Bollmann, Andreas</creator><creator>Koutalas, Emmanuel</creator><creator>Mussigbrodt, Andreas</creator><creator>Sommer, Phillipp</creator><creator>Arya, Arash</creator><creator>Richter, Sergio</creator><creator>Hindricks, Gerhard</creator><creator>Breithardt, Ole A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy</title><author>Kosiuk, Jedrzej ; Dinov, Borislav ; Bollmann, Andreas ; Koutalas, Emmanuel ; Mussigbrodt, Andreas ; Sommer, Phillipp ; Arya, Arash ; Richter, Sergio ; Hindricks, Gerhard ; Breithardt, Ole A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-313fc9ca43f7d236d630e89204aac324c3eedaca2d97e472b8bfdf588b29b26a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Cardiology</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Echocardiography - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Risk</topic><topic>Tachycardia, Ventricular - epidemiology</topic><topic>Tachycardia, Ventricular - physiopathology</topic><topic>Time Factors</topic><topic>Ventricular Fibrillation - epidemiology</topic><topic>Ventricular Fibrillation - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kosiuk, Jedrzej</creatorcontrib><creatorcontrib>Dinov, Borislav</creatorcontrib><creatorcontrib>Bollmann, Andreas</creatorcontrib><creatorcontrib>Koutalas, Emmanuel</creatorcontrib><creatorcontrib>Mussigbrodt, Andreas</creatorcontrib><creatorcontrib>Sommer, Phillipp</creatorcontrib><creatorcontrib>Arya, Arash</creatorcontrib><creatorcontrib>Richter, Sergio</creatorcontrib><creatorcontrib>Hindricks, Gerhard</creatorcontrib><creatorcontrib>Breithardt, Ole A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kosiuk, Jedrzej</au><au>Dinov, Borislav</au><au>Bollmann, Andreas</au><au>Koutalas, Emmanuel</au><au>Mussigbrodt, Andreas</au><au>Sommer, Phillipp</au><au>Arya, Arash</au><au>Richter, Sergio</au><au>Hindricks, Gerhard</au><au>Breithardt, Ole A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy</atitle><jtitle>Clinical research in cardiology</jtitle><stitle>Clin Res Cardiol</stitle><addtitle>Clin Res Cardiol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>104</volume><issue>12</issue><spage>1072</spage><epage>1077</epage><pages>1072-1077</pages><issn>1861-0684</issn><eissn>1861-0692</eissn><abstract>Background
Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied.
Methods and results
In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15–58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms,
p
= 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63–1.00,
p
= 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1–143.4,
p
= 0.024).
Conclusions
In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26025592</pmid><doi>10.1007/s00392-015-0875-7</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Cardiology Cardiomyopathies - physiopathology Echocardiography - methods Female Humans Incidence Male Medicine Medicine & Public Health Middle Aged Original Paper Risk Tachycardia, Ventricular - epidemiology Tachycardia, Ventricular - physiopathology Time Factors Ventricular Fibrillation - epidemiology Ventricular Fibrillation - physiopathology |
| title | Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy |
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