Antibody-Mediated Inhibition of the FGFR1c Isoform Induces a Catabolic Lean State in Siberian Hamsters

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) that selectively antagonizes the FGFR1c isoform [2],...

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Veröffentlicht in:	Current biology 2015-11, Vol.25 (22), p.2997-3003
Hauptverfasser:	Samms, Ricardo J., Lewis, Jo E., Lory, Alex, Fowler, Maxine J., Cooper, Scott, Warner, Amy, Emmerson, Paul, Adams, Andrew C., Luckett, Jeni C., Perkins, Alan C., Wilson, Dana, Barrett, Perry, Tsintzas, Kostas, Ebling, Francis J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - physiology Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Circadian Rhythm - physiology Cricetinae Eating - drug effects Hypothalamus - metabolism Male Models, Animal Phodopus Photoperiod Protein Isoforms - metabolism Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1 - immunology Receptor, Fibroblast Growth Factor, Type 1 - metabolism Thinness - metabolism Thyroid Hormones - metabolism Weight Loss - drug effects
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