G‑Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

Human telomere DNA (Htelo) and telomeric repeat-containing RNA (TERRA) are integral telomere components containing the short DNA repeats d(TTAGGG) and RNA repeats r(UUAGGG), respectively. Htelo and TERRA form G-quadruplexes, but the biological significance of their G-quadruplex formation in telome...

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Veröffentlicht in:	ACS chemical biology 2015-11, Vol.10 (11), p.2564-2569
Hauptverfasser:	Takahama, Kentaro, Miyawaki, Arisa, Shitara, Takumi, Mitsuya, Keita, Morikawa, Masayuki, Hagihara, Masaki, Kino, Katsuhito, Yamamoto, Ayumu, Oyoshi, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - chemistry Arginine - genetics Circular Dichroism DNA - chemistry Electrophoretic Mobility Shift Assay G-Quadruplexes Glycine - chemistry Glycine - genetics HeLa Cells Humans Protein Engineering Protein Structure, Tertiary - genetics Repetitive Sequences, Nucleic Acid - genetics RNA - chemistry RNA-Binding Proteins - chemical synthesis RNA-Binding Proteins - chemistry
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