Synthesis, quorum sensing inhibition and docking studies of 1,5-dihydropyrrol-2-ones

[Display omitted] Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli use N-acylated l-homoserine lactones (AHLs) as autoinducers (AIs) for quorum sensing (QS), a chief regulatory and cell-to-cell communication system. QS is responsible for social adaptation, virulence factor...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-12, Vol.23 (23), p.7366-7377
Hauptverfasser:	Goh, Wai-Kean, Gardner, Christopher R., Chandra Sekhar, Kondapalli V.G., Biswas, Nripendra N., Nizalapur, Shashidhar, Rice, Scott A., Willcox, Mark, Black, David StC, Kumar, Naresh
Format:	Artikel
Sprache:	eng
Schlagworte:	1,5-Dihydropyrrol-2-ones Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Bacterial Proteins - chemistry Escherichia coli - drug effects Gram-negative bacteria Lactams - chemical synthesis Lactams - chemistry Lactams - pharmacology Microbial Sensitivity Tests Molecular Docking Simulation N-Acylated l-homoserine lactones Pyrrolidinones - chemical synthesis Pyrrolidinones - chemistry Pyrrolidinones - pharmacology Quorum sensing Quorum Sensing - drug effects Trans-Activators - chemistry
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