Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Abstract Background Psychiatric disorders such as schizophrenia are worsened by stress, and working memory deficits are often a central feature of illness. Working memory is mediated by the persistent firing of prefrontal cortical (PFC) pyramidal neurons. Stress impairs working memory via high level...

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Veröffentlicht in:	Biological psychiatry (1969) 2015-12, Vol.78 (12), p.860-870
Hauptverfasser:	Gamo, Nao J, Lur, Gyorgy, Higley, Michael J, Wang, Min, Paspalas, Constantinos D, Vijayraghavan, Susheel, Yang, Yang, Ramos, Brian P, Peng, Kathy, Kata, Anna, Boven, Lindsay, Lin, Faith, Roman, Lisette, Lee, Daeyeol, Arnsten, Amy F.T
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Action Potentials - drug effects Animals cAMP D1 dopamine receptor Dendritic Spines - metabolism Dendritic Spines - ultrastructure HCN channel Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology Macaca mulatta Male Memory, Short-Term - physiology Mice Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Prefrontal Cortex - ultrastructure Psychiatry Pyramidal Cells - drug effects Pyramidal Cells - physiology Pyramidal Cells - ultrastructure Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - metabolism Receptors, Dopamine D1 - physiology Stress Stress, Physiological Synapses - metabolism Synapses - ultrastructure Working memory
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