Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study
To evaluate the short-term outcome of the decision taken by the Hepatoma Board for the treatment of Hepatocellular carcinoma (HCC). This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients w...
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| Veröffentlicht in: | The Turkish journal of gastroenterology 2015-11, Vol.26 (6), p.498-505 |
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| container_title | The Turkish journal of gastroenterology |
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| creator | Zaky, Saad Makhlouf, Nahed A Abdel Malek, Mohamed O Bakheet, Ahmed A Seif, Hany M A Hamza, Hesham M Sabry, Abeer M M |
| description | To evaluate the short-term outcome of the decision taken by the Hepatoma Board for the treatment of Hepatocellular carcinoma (HCC).
This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients were as follows: 1- surgical resection (7 patients), 2- local ablative therapy (LAT) (22 patients), 3- conventional transarterial chemoembolization (TACE) (24 patients), and 4- palliative supportive care (21 patients).
The short-term mortality rate was 25.7% of the total patients. The success rate was nearly equal in LAT (68.2%) and surgery (71.4%), whereas the success rate was approximately 33.3% in TACE. There was no difference in the mean total bilirubin level before and after LAT, surgery, or TACE (p>0.05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000). There was a decrease in the mean alpha fetoprotein level after surgery and LAT (p=0.033) for surgery and (p=0.048) for LAT.
The management of HCC is better performed through a multidisciplinary team decision. Surgery has comparable outcome to LAT but is more invasive. According to our local experience, conventional TACE has a success rate of 33.3%. |
| doi_str_mv | 10.5152/tjg.2015.0158 |
| format | Article |
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This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients were as follows: 1- surgical resection (7 patients), 2- local ablative therapy (LAT) (22 patients), 3- conventional transarterial chemoembolization (TACE) (24 patients), and 4- palliative supportive care (21 patients).
The short-term mortality rate was 25.7% of the total patients. The success rate was nearly equal in LAT (68.2%) and surgery (71.4%), whereas the success rate was approximately 33.3% in TACE. There was no difference in the mean total bilirubin level before and after LAT, surgery, or TACE (p>0.05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000). There was a decrease in the mean alpha fetoprotein level after surgery and LAT (p=0.033) for surgery and (p=0.048) for LAT.
The management of HCC is better performed through a multidisciplinary team decision. Surgery has comparable outcome to LAT but is more invasive. According to our local experience, conventional TACE has a success rate of 33.3%.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2015.0158</identifier><identifier>PMID: 26510081</identifier><language>eng</language><publisher>Turkey</publisher><subject>Ablation Techniques - mortality ; Adult ; Aged ; alpha-Fetoproteins - analysis ; Bilirubin - blood ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - therapy ; Chemoembolization, Therapeutic - mortality ; Clinical Decision-Making - methods ; Disease Management ; Female ; Humans ; Liver - surgery ; Liver Neoplasms - blood ; Liver Neoplasms - mortality ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Palliative Care ; Patient Care Team ; Prospective Studies ; Serum Albumin - analysis ; Treatment Outcome</subject><ispartof>The Turkish journal of gastroenterology, 2015-11, Vol.26 (6), p.498-505</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-ab809d3893c7ca75cc4cb6afbd69e1e199deba78ade4880e2d4d752b0cb4a6513</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26510081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaky, Saad</creatorcontrib><creatorcontrib>Makhlouf, Nahed A</creatorcontrib><creatorcontrib>Abdel Malek, Mohamed O</creatorcontrib><creatorcontrib>Bakheet, Ahmed A</creatorcontrib><creatorcontrib>Seif, Hany M A</creatorcontrib><creatorcontrib>Hamza, Hesham M</creatorcontrib><creatorcontrib>Sabry, Abeer M M</creatorcontrib><title>Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study</title><title>The Turkish journal of gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>To evaluate the short-term outcome of the decision taken by the Hepatoma Board for the treatment of Hepatocellular carcinoma (HCC).
This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients were as follows: 1- surgical resection (7 patients), 2- local ablative therapy (LAT) (22 patients), 3- conventional transarterial chemoembolization (TACE) (24 patients), and 4- palliative supportive care (21 patients).
The short-term mortality rate was 25.7% of the total patients. The success rate was nearly equal in LAT (68.2%) and surgery (71.4%), whereas the success rate was approximately 33.3% in TACE. There was no difference in the mean total bilirubin level before and after LAT, surgery, or TACE (p>0.05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000). There was a decrease in the mean alpha fetoprotein level after surgery and LAT (p=0.033) for surgery and (p=0.048) for LAT.
The management of HCC is better performed through a multidisciplinary team decision. Surgery has comparable outcome to LAT but is more invasive. According to our local experience, conventional TACE has a success rate of 33.3%.</description><subject>Ablation Techniques - mortality</subject><subject>Adult</subject><subject>Aged</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Bilirubin - blood</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Chemoembolization, Therapeutic - mortality</subject><subject>Clinical Decision-Making - methods</subject><subject>Disease Management</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - surgery</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Palliative Care</subject><subject>Patient Care Team</subject><subject>Prospective Studies</subject><subject>Serum Albumin - analysis</subject><subject>Treatment Outcome</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kElPwzAQRi0EoqVw5Ip85JLiJYvDrarYpCIucI4m9iR1yUbsHPrvcdXCYTQa6enTfI-QW86WCU_Eg9_VS8F4sgyjzshc8FhFScqyczLnkrEozmM1I1fO7RiTiqfiksxEmnDGFJ-T-n1qvDXWaTs0toNxTw1q62zf0Ra-bVdT21G_xXB1UGOLnad9Rbc4gO81Ns3UwEg1jNp2fQuPdEW3vRushyYqwaGhzk9mf00uKmgc3pz2gnw9P32uX6PNx8vberWJtMilj6BULDdS5VJnGrJE61iXKVSlSXPkyPPcYAmZAoOxUgyFiU2WiJLpMoZQSi7I_TF3GPufCZ0v2tAtvAkd9pMreCYTKVQcXCxIdET12Ds3YlUMo22DgYKz4uC2CG6Lg9vi4Dbwd6foqWzR_NN_MuUvWQV3cg</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Zaky, Saad</creator><creator>Makhlouf, Nahed A</creator><creator>Abdel Malek, Mohamed O</creator><creator>Bakheet, Ahmed A</creator><creator>Seif, Hany M A</creator><creator>Hamza, Hesham M</creator><creator>Sabry, Abeer M M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study</title><author>Zaky, Saad ; Makhlouf, Nahed A ; Abdel Malek, Mohamed O ; Bakheet, Ahmed A ; Seif, Hany M A ; Hamza, Hesham M ; Sabry, Abeer M M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-ab809d3893c7ca75cc4cb6afbd69e1e199deba78ade4880e2d4d752b0cb4a6513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ablation Techniques - mortality</topic><topic>Adult</topic><topic>Aged</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Bilirubin - blood</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Chemoembolization, Therapeutic - mortality</topic><topic>Clinical Decision-Making - methods</topic><topic>Disease Management</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - surgery</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Palliative Care</topic><topic>Patient Care Team</topic><topic>Prospective Studies</topic><topic>Serum Albumin - analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaky, Saad</creatorcontrib><creatorcontrib>Makhlouf, Nahed A</creatorcontrib><creatorcontrib>Abdel Malek, Mohamed O</creatorcontrib><creatorcontrib>Bakheet, Ahmed A</creatorcontrib><creatorcontrib>Seif, Hany M A</creatorcontrib><creatorcontrib>Hamza, Hesham M</creatorcontrib><creatorcontrib>Sabry, Abeer M M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Turkish journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaky, Saad</au><au>Makhlouf, Nahed A</au><au>Abdel Malek, Mohamed O</au><au>Bakheet, Ahmed A</au><au>Seif, Hany M A</au><au>Hamza, Hesham M</au><au>Sabry, Abeer M M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study</atitle><jtitle>The Turkish journal of gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>26</volume><issue>6</issue><spage>498</spage><epage>505</epage><pages>498-505</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>To evaluate the short-term outcome of the decision taken by the Hepatoma Board for the treatment of Hepatocellular carcinoma (HCC).
This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients were as follows: 1- surgical resection (7 patients), 2- local ablative therapy (LAT) (22 patients), 3- conventional transarterial chemoembolization (TACE) (24 patients), and 4- palliative supportive care (21 patients).
The short-term mortality rate was 25.7% of the total patients. The success rate was nearly equal in LAT (68.2%) and surgery (71.4%), whereas the success rate was approximately 33.3% in TACE. There was no difference in the mean total bilirubin level before and after LAT, surgery, or TACE (p>0.05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000). There was a decrease in the mean alpha fetoprotein level after surgery and LAT (p=0.033) for surgery and (p=0.048) for LAT.
The management of HCC is better performed through a multidisciplinary team decision. Surgery has comparable outcome to LAT but is more invasive. According to our local experience, conventional TACE has a success rate of 33.3%.</abstract><cop>Turkey</cop><pmid>26510081</pmid><doi>10.5152/tjg.2015.0158</doi><tpages>8</tpages></addata></record> |
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| subjects | Ablation Techniques - mortality Adult Aged alpha-Fetoproteins - analysis Bilirubin - blood Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - therapy Chemoembolization, Therapeutic - mortality Clinical Decision-Making - methods Disease Management Female Humans Liver - surgery Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - therapy Male Middle Aged Palliative Care Patient Care Team Prospective Studies Serum Albumin - analysis Treatment Outcome |
| title | Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study |
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