Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder
Abstract Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physi...
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| Veröffentlicht in: | Psychiatry research 2015-12, Vol.230 (2), p.394-399 |
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| creator | Yamamuro, Kazuhiko Ota, Toyosaku Nakanishi, Yoko Matsuura, Hiroki Okazaki, Kosuke Kishimoto, Naoko Takahashi, Hiroyuki Iwasaka, Hidemi Iida, Junzo Kishimoto, Toshifumi |
| description | Abstract Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale–Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores. |
| doi_str_mv | 10.1016/j.psychres.2015.09.026 |
| format | Article |
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Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale–Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2015.09.026</identifier><identifier>PMID: 26410771</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acoustic Stimulation - methods ; Adolescent ; Child ; Event related potentials ; Event-Related Potentials, P300 - physiology ; Evoked Potentials - physiology ; Female ; Healthy Volunteers ; Humans ; Male ; Mental Processes - physiology ; Mismatch negativity ; Obsessive-compulsive disorder ; Obsessive-Compulsive Disorder - physiopathology ; P300 ; Psychiatry ; Task Performance and Analysis</subject><ispartof>Psychiatry research, 2015-12, Vol.230 (2), p.394-399</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-b2b8d09f5227531bd0e94817d0ce85b06eedd03ac6b57a61bea3b2ec3960fd083</citedby><cites>FETCH-LOGICAL-c423t-b2b8d09f5227531bd0e94817d0ce85b06eedd03ac6b57a61bea3b2ec3960fd083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178115303504$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26410771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamuro, Kazuhiko</creatorcontrib><creatorcontrib>Ota, Toyosaku</creatorcontrib><creatorcontrib>Nakanishi, Yoko</creatorcontrib><creatorcontrib>Matsuura, Hiroki</creatorcontrib><creatorcontrib>Okazaki, Kosuke</creatorcontrib><creatorcontrib>Kishimoto, Naoko</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Iwasaka, Hidemi</creatorcontrib><creatorcontrib>Iida, Junzo</creatorcontrib><creatorcontrib>Kishimoto, Toshifumi</creatorcontrib><title>Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale–Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.</description><subject>Acoustic Stimulation - methods</subject><subject>Adolescent</subject><subject>Child</subject><subject>Event related potentials</subject><subject>Event-Related Potentials, P300 - physiology</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Male</subject><subject>Mental Processes - physiology</subject><subject>Mismatch negativity</subject><subject>Obsessive-compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - physiopathology</subject><subject>P300</subject><subject>Psychiatry</subject><subject>Task Performance and Analysis</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EotvCK1Q5ckmYsddxckGgqkClShxajsjyn1nqJZsEO9lqn6oPwYvV0bYcuHAaj_TNb-RvGDtHqBCwfr-txnRwd5FSxQFlBW0FvH7BVtgoXirk4iVbZVCWqBo8YacpbQGAY9u-Zie8XiMohSv243JP_VRG6sxEvhiHKbfBdKkIfeHj_LPszZ-HPRUj-WCmGFwxmilkKBX3YborBpsopbCn0g27ce6WZ-FDGqKn-Ia92uQsevtUz9j3z5e3F1_L629fri4-XZduzcVUWm4bD-1Gcq6kQOuB2nWDyoOjRlqoibwHYVxtpTI1WjLCcnKirWHjoRFn7N0xd4zD75nSpHchOeo609MwJ41KSJGzW8xofURdHFKKtNFjDDsTDxpBL2r1Vj-r1YtaDa3OavPg-dOO2e7I_x17dpmBj0eA8k_3gaJOLotyWVwkN2k_hP_v-PBPhOtCH5zpftGB0naYY589atSJa9A3y4GX-6IUICSsxSMe86Xo</recordid><startdate>20151215</startdate><enddate>20151215</enddate><creator>Yamamuro, Kazuhiko</creator><creator>Ota, Toyosaku</creator><creator>Nakanishi, Yoko</creator><creator>Matsuura, Hiroki</creator><creator>Okazaki, Kosuke</creator><creator>Kishimoto, Naoko</creator><creator>Takahashi, Hiroyuki</creator><creator>Iwasaka, Hidemi</creator><creator>Iida, Junzo</creator><creator>Kishimoto, Toshifumi</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151215</creationdate><title>Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder</title><author>Yamamuro, Kazuhiko ; Ota, Toyosaku ; Nakanishi, Yoko ; Matsuura, Hiroki ; Okazaki, Kosuke ; Kishimoto, Naoko ; Takahashi, Hiroyuki ; Iwasaka, Hidemi ; Iida, Junzo ; Kishimoto, Toshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-b2b8d09f5227531bd0e94817d0ce85b06eedd03ac6b57a61bea3b2ec3960fd083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Adolescent</topic><topic>Child</topic><topic>Event related potentials</topic><topic>Event-Related Potentials, P300 - physiology</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Processes - physiology</topic><topic>Mismatch negativity</topic><topic>Obsessive-compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - physiopathology</topic><topic>P300</topic><topic>Psychiatry</topic><topic>Task Performance and Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamuro, Kazuhiko</creatorcontrib><creatorcontrib>Ota, Toyosaku</creatorcontrib><creatorcontrib>Nakanishi, Yoko</creatorcontrib><creatorcontrib>Matsuura, Hiroki</creatorcontrib><creatorcontrib>Okazaki, Kosuke</creatorcontrib><creatorcontrib>Kishimoto, Naoko</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Iwasaka, Hidemi</creatorcontrib><creatorcontrib>Iida, Junzo</creatorcontrib><creatorcontrib>Kishimoto, Toshifumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamuro, Kazuhiko</au><au>Ota, Toyosaku</au><au>Nakanishi, Yoko</au><au>Matsuura, Hiroki</au><au>Okazaki, Kosuke</au><au>Kishimoto, Naoko</au><au>Takahashi, Hiroyuki</au><au>Iwasaka, Hidemi</au><au>Iida, Junzo</au><au>Kishimoto, Toshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2015-12-15</date><risdate>2015</risdate><volume>230</volume><issue>2</issue><spage>394</spage><epage>399</epage><pages>394-399</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Abstract Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale–Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. 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| subjects | Acoustic Stimulation - methods Adolescent Child Event related potentials Event-Related Potentials, P300 - physiology Evoked Potentials - physiology Female Healthy Volunteers Humans Male Mental Processes - physiology Mismatch negativity Obsessive-compulsive disorder Obsessive-Compulsive Disorder - physiopathology P300 Psychiatry Task Performance and Analysis |
| title | Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder |
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