Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action

[Display omitted] A series of novel acylhydrazone derivatives were designed, synthesized and evaluated for their potential cytotoxic effects against human cancer cell lines. The preliminary results indicated that some of the obtained compounds (such as 8b, 13c) exhibited good to moderate cytotoxic a...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-12, Vol.25 (24), p.5772-5776
Hauptverfasser:	Yu, Xifang, Shi, Liqiao, Ke, Shaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylhydrazone Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Cell Line, Tumor Cytotoxic activity Drug Screening Assays, Antitumor Fluorouracil - toxicity Hep G2 Cells Humans Hydrazones - chemical synthesis Hydrazones - chemistry Hydrazones - toxicity Synthesis
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