The MLL Gene and Translocations Involving Chromosomal Band 11q23 in Acute Leukemia
Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes involved in carcinogenesis. Molecular studies of the...
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| Veröffentlicht in: | Anticancer research 2005-05, Vol.25 (3B), p.1931-1944 |
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| container_title | Anticancer research |
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| creator | DE BRAEKELEER, Marc MOREL, Frédéric LE BRIS, Marie-Josée HERRY, Angèle DOUET-GUILBERT, Nathalie |
| description | Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes
located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes
involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23
led to the cloning of a gene that was named MLL. Based on 7969 cases of acute myeloblastic leukemia (AML) and 1252 cases of
acute lymphoblastic leukemia (ALL) taken from the literature, band 11q23 and/or the MLL gene was involved in 5.2% of AML and
22% of ALL. Differences in the frequency and the distribution of translocations were noted according to the type of acute
leukemia and age of the patients. Seventy-five different rearrangements involving band 11q23 have so far been identified,
39 MLL partner genes having been cloned. The fusion of MLL and its partner gene leads to a gain of function of the MLL gene.
The accumulating data suggests that the fusion protein affects the differentiation of the hematopoietic pluripotent stem cells
or the lymphoid or myeloid committed stem cells by deregulating the HOX gene expression patterns. |
| format | Article |
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located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes
involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23
led to the cloning of a gene that was named MLL. Based on 7969 cases of acute myeloblastic leukemia (AML) and 1252 cases of
acute lymphoblastic leukemia (ALL) taken from the literature, band 11q23 and/or the MLL gene was involved in 5.2% of AML and
22% of ALL. Differences in the frequency and the distribution of translocations were noted according to the type of acute
leukemia and age of the patients. Seventy-five different rearrangements involving band 11q23 have so far been identified,
39 MLL partner genes having been cloned. The fusion of MLL and its partner gene leads to a gain of function of the MLL gene.
The accumulating data suggests that the fusion protein affects the differentiation of the hematopoietic pluripotent stem cells
or the lymphoid or myeloid committed stem cells by deregulating the HOX gene expression patterns.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16158928</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Biological and medical sciences ; Chromosome aberrations ; Chromosome Banding ; Chromosomes, Human, Pair 11 - genetics ; DNA-Binding Proteins - genetics ; Histone-Lysine N-Methyltransferase ; Humans ; Leukemia, Myeloid, Acute - genetics ; Medical genetics ; Medical sciences ; Myeloid-Lymphoid Leukemia Protein ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Proto-Oncogenes - genetics ; Transcription Factors - genetics ; Translocation, Genetic ; Tumors</subject><ispartof>Anticancer research, 2005-05, Vol.25 (3B), p.1931-1944</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16908587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16158928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE BRAEKELEER, Marc</creatorcontrib><creatorcontrib>MOREL, Frédéric</creatorcontrib><creatorcontrib>LE BRIS, Marie-Josée</creatorcontrib><creatorcontrib>HERRY, Angèle</creatorcontrib><creatorcontrib>DOUET-GUILBERT, Nathalie</creatorcontrib><title>The MLL Gene and Translocations Involving Chromosomal Band 11q23 in Acute Leukemia</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes
located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes
involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23
led to the cloning of a gene that was named MLL. Based on 7969 cases of acute myeloblastic leukemia (AML) and 1252 cases of
acute lymphoblastic leukemia (ALL) taken from the literature, band 11q23 and/or the MLL gene was involved in 5.2% of AML and
22% of ALL. Differences in the frequency and the distribution of translocations were noted according to the type of acute
leukemia and age of the patients. Seventy-five different rearrangements involving band 11q23 have so far been identified,
39 MLL partner genes having been cloned. The fusion of MLL and its partner gene leads to a gain of function of the MLL gene.
The accumulating data suggests that the fusion protein affects the differentiation of the hematopoietic pluripotent stem cells
or the lymphoid or myeloid committed stem cells by deregulating the HOX gene expression patterns.</description><subject>Biological and medical sciences</subject><subject>Chromosome aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Histone-Lysine N-Methyltransferase</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Myeloid-Lymphoid Leukemia Protein</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Proto-Oncogenes - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Translocation, Genetic</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0FFLwzAUBeAgipvTvyB50bdCkrs0yeM2dAoVQeZzSNt0jbbJ1rQT_70VJ_p0Xz7O4Z4TNKVC0URwIKdoShgniSCET9BFjG-EpKmScI4mNKVcKian6GVTW_yUZXhtvcXGl3jTGR-bUJjeBR_xoz-E5uD8Fq_qLrQhhtY0ePktKd0zwM7jRTH0Fmd2eLetM5forDJNtFfHO0Ov93eb1UOSPa8fV4ssqYHQPpEUchCiYlQJwm2Ry4KkkOdElkB5ZYjKWT6XEpRQhnPKLJRmfKaUc5YTZmCGbn9yd13YDzb2unWxsE1jvA1D1FQAZ6DICK-PcMhbW-pd51rTferfFUZwcwQmFqapxgUKF_85RSSX4q-xdtv6w3VWx3GMZowFbTrGNSw1VUDhC56McP0</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>DE BRAEKELEER, Marc</creator><creator>MOREL, Frédéric</creator><creator>LE BRIS, Marie-Josée</creator><creator>HERRY, Angèle</creator><creator>DOUET-GUILBERT, Nathalie</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20050501</creationdate><title>The MLL Gene and Translocations Involving Chromosomal Band 11q23 in Acute Leukemia</title><author>DE BRAEKELEER, Marc ; MOREL, Frédéric ; LE BRIS, Marie-Josée ; HERRY, Angèle ; DOUET-GUILBERT, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-813b377f219705ecb8c063bb08d315fa09b2b4883979a5512e3da700d842b02a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Chromosome aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Histone-Lysine N-Methyltransferase</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Myeloid-Lymphoid Leukemia Protein</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Proto-Oncogenes - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Translocation, Genetic</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE BRAEKELEER, Marc</creatorcontrib><creatorcontrib>MOREL, Frédéric</creatorcontrib><creatorcontrib>LE BRIS, Marie-Josée</creatorcontrib><creatorcontrib>HERRY, Angèle</creatorcontrib><creatorcontrib>DOUET-GUILBERT, Nathalie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE BRAEKELEER, Marc</au><au>MOREL, Frédéric</au><au>LE BRIS, Marie-Josée</au><au>HERRY, Angèle</au><au>DOUET-GUILBERT, Nathalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The MLL Gene and Translocations Involving Chromosomal Band 11q23 in Acute Leukemia</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>25</volume><issue>3B</issue><spage>1931</spage><epage>1944</epage><pages>1931-1944</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes
located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes
involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23
led to the cloning of a gene that was named MLL. Based on 7969 cases of acute myeloblastic leukemia (AML) and 1252 cases of
acute lymphoblastic leukemia (ALL) taken from the literature, band 11q23 and/or the MLL gene was involved in 5.2% of AML and
22% of ALL. Differences in the frequency and the distribution of translocations were noted according to the type of acute
leukemia and age of the patients. Seventy-five different rearrangements involving band 11q23 have so far been identified,
39 MLL partner genes having been cloned. The fusion of MLL and its partner gene leads to a gain of function of the MLL gene.
The accumulating data suggests that the fusion protein affects the differentiation of the hematopoietic pluripotent stem cells
or the lymphoid or myeloid committed stem cells by deregulating the HOX gene expression patterns.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16158928</pmid><tpages>14</tpages></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Biological and medical sciences Chromosome aberrations Chromosome Banding Chromosomes, Human, Pair 11 - genetics DNA-Binding Proteins - genetics Histone-Lysine N-Methyltransferase Humans Leukemia, Myeloid, Acute - genetics Medical genetics Medical sciences Myeloid-Lymphoid Leukemia Protein Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogenes - genetics Transcription Factors - genetics Translocation, Genetic Tumors |
| title | The MLL Gene and Translocations Involving Chromosomal Band 11q23 in Acute Leukemia |
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