General mechanisms of axonal damage and its prevention

Axonal degeneration is a prominent pathological feature in multiple sclerosis observed over a century ago. The gradual loss of axons is thought to underlie irreversible clinical deficits in this disease. The precise mechanisms of axonopathy are poorly understood, but likely involve excess accumulati...

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Veröffentlicht in:	Journal of the neurological sciences 2005-06, Vol.233 (1), p.3-13
1. Verfasser:	Stys, Peter K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Axonal degeneration Axons - drug effects Axons - pathology Axons - ultrastructure Biological and medical sciences Calcium - metabolism Delivery. Postpartum. Lactation Disorders Extracellular Space - metabolism Gynecology. Andrology. Obstetrics Humans Injuries of the nervous system and the skull. Diseases due to physical agents Ischemia - complications Ischemia - pathology Medical sciences Models, Biological Nerve Degeneration - etiology Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Degeneration - prevention & control Nerve Fibers, Myelinated - pathology Nerve Fibers, Myelinated - physiology Neural Conduction - drug effects Neural Conduction - physiology Neurology Neurotoxins - toxicity Sodium Channels - physiology Time Factors Traumas. Diseases due to physical agents
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