Autophagy Promotes MHC Class II Presentation of Peptides from Intracellular Source Proteins
MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2005-05, Vol.102 (22), p.7922-7927 |
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| creator | Dengjel, Jörn Schoor, Oliver Fischer, Rainer Reich, Michael Kraus, Marianne Müller, Margret Kreymborg, Katharina Altenberend, Florian Brandenburg, Jens Kalbacher, Hubert Brock, Roland Driessen, Christoph Rammensee, Hans-Georg Stevanovic, Stefan Cresswell, Peter |
| description | MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The presentation of peptides from intracellular and lysosomal source proteins was strongly increased on MHC-II in contrast with peptides from membrane and secreted proteins. In addition, autophagy influenced the MHC-II antigen-processing machinery. Our study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4+T cell-mediated processes. |
| doi_str_mv | 10.1073/pnas.0501190102 |
| format | Article |
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In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The presentation of peptides from intracellular and lysosomal source proteins was strongly increased on MHC-II in contrast with peptides from membrane and secreted proteins. In addition, autophagy influenced the MHC-II antigen-processing machinery. Our study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4+T cell-mediated processes.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0501190102</identifier><identifier>PMID: 15894616</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Amino Acid Sequence ; Antigen Presentation - immunology ; Antigens ; Autophagy - immunology ; B-Lymphocytes - immunology ; Biological Sciences ; Cadaverine - analogs & derivatives ; Cell lines ; Cysteine Endopeptidases - metabolism ; Gene expression ; Gene Expression - immunology ; Histocompatibility Antigens Class II - immunology ; Histocompatibility Antigens Class II - metabolism ; Humans ; Ligands ; Lysosomes - immunology ; Lysosomes - metabolism ; Membrane proteins ; Messenger RNA ; Molecules ; Oligonucleotide Array Sequence Analysis ; Peptides - genetics ; Peptides - immunology ; Peptides - metabolism ; Starvation ; T lymphocytes ; Vacuoles</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (22), p.7922-7927</ispartof><rights>Copyright 1993/2005 The National Academy of Sciences of the United States of America</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-4dccb6e4d595954465e6a43e7c4384f7d02e9560756a1ff9ff3efb828afdb3ef3</citedby><cites>FETCH-LOGICAL-c566t-4dccb6e4d595954465e6a43e7c4384f7d02e9560756a1ff9ff3efb828afdb3ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/22.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3375695$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3375695$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15894616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dengjel, Jörn</creatorcontrib><creatorcontrib>Schoor, Oliver</creatorcontrib><creatorcontrib>Fischer, Rainer</creatorcontrib><creatorcontrib>Reich, Michael</creatorcontrib><creatorcontrib>Kraus, Marianne</creatorcontrib><creatorcontrib>Müller, Margret</creatorcontrib><creatorcontrib>Kreymborg, Katharina</creatorcontrib><creatorcontrib>Altenberend, Florian</creatorcontrib><creatorcontrib>Brandenburg, Jens</creatorcontrib><creatorcontrib>Kalbacher, Hubert</creatorcontrib><creatorcontrib>Brock, Roland</creatorcontrib><creatorcontrib>Driessen, Christoph</creatorcontrib><creatorcontrib>Rammensee, Hans-Georg</creatorcontrib><creatorcontrib>Stevanovic, Stefan</creatorcontrib><creatorcontrib>Cresswell, Peter</creatorcontrib><title>Autophagy Promotes MHC Class II Presentation of Peptides from Intracellular Source Proteins</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The presentation of peptides from intracellular and lysosomal source proteins was strongly increased on MHC-II in contrast with peptides from membrane and secreted proteins. In addition, autophagy influenced the MHC-II antigen-processing machinery. 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| subjects | Amino Acid Sequence Antigen Presentation - immunology Antigens Autophagy - immunology B-Lymphocytes - immunology Biological Sciences Cadaverine - analogs & derivatives Cell lines Cysteine Endopeptidases - metabolism Gene expression Gene Expression - immunology Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans Ligands Lysosomes - immunology Lysosomes - metabolism Membrane proteins Messenger RNA Molecules Oligonucleotide Array Sequence Analysis Peptides - genetics Peptides - immunology Peptides - metabolism Starvation T lymphocytes Vacuoles |
| title | Autophagy Promotes MHC Class II Presentation of Peptides from Intracellular Source Proteins |
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