SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

Mice lacking suppressor of cytokine signaling-1 (SOCS1) develop a complex fatal neonatal disease. In this study, SOCS1-/- mice were shown to exhibit excessive responses typical of those induced by interferon gamma (IFNgamma), were hyperresponsive to viral infection, and yielded macrophages with an e...

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Veröffentlicht in:	Cell 1999-09, Vol.98 (5), p.597-608
Hauptverfasser:	Alexander, W S, Starr, R, Fenner, J E, Scott, C L, Handman, E, Sprigg, N S, Corbin, J E, Cornish, A L, Darwiche, R, Owczarek, C M, Kay, T W, Nicola, N A, Hertzog, P J, Metcalf, D, Hilton, D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphavirus Infections - mortality Alphavirus Infections - prevention & control Animals Carrier Proteins - physiology Disease Susceptibility Gene Expression Regulation, Developmental Interferon-gamma - antagonists & inhibitors Interferon-gamma - pharmacology Interferon-gamma - physiology Leishmania major - immunology Leishmaniasis - mortality Leishmaniasis - prevention & control Lymphopenia - mortality Lymphopenia - prevention & control Macrophages - drug effects Mice Mice, Inbred C57BL Mice, Mutant Strains Repressor Proteins Semliki forest virus - immunology Semliki forest virus - metabolism Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
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