Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus

Abstract Objective Since benzodiazepines (BZPs) became clinically available for the treatment of status epilepticus (SE) in children, the incidence of neurological sequelae has increased. However, the cause–effect relationship is poorly understood. In this paper, we examined the effect of BZPs on an...

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Veröffentlicht in:	Epilepsy & behavior 2015-11, Vol.52 (Pt A), p.180-186
Hauptverfasser:	Nakajima, Keisuke, Hirai, Shinobu, Morio, Tomohiro, Okado, Haruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - therapeutic use Apoptosis - drug effects Benzodiazepine Benzodiazepines - therapeutic use Children Convulsants Exploratory Behavior - drug effects GABA Agonists - pharmacology GABA-A receptor Inflammation Inflammation - chemically induced Inflammation - complications Inflammation - psychology Male Mice Mice, Inbred C57BL Midazolam - pharmacology Neurology Neurons - drug effects Parvalbumins Pilocarpine Poly I-C Receptors, GABA-A - drug effects Seizures - chemically induced Seizures - drug therapy Seizures - psychology Status epilepticus Status Epilepticus - drug therapy Status Epilepticus - etiology Status Epilepticus - psychology
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