A procoagulant chemically sulfated mannan

•Sulfation of a mannan from yeast extract, an easily and inexpensive source.•Sulfated mannan was structurally characterized by GC–MS and NMR.•Sulfated mannan had a procoagulant effect on blood coagulation models. Disorders of hemostasis can produce innumerous problems. Polysaccharides have been stud...

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Veröffentlicht in:	Carbohydrate polymers 2016-01, Vol.136, p.177-186
Hauptverfasser:	Gracher, Ana Helena P., Santana, Aline G., Cipriani, Thales R., Iacomini, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation - drug effects Chemical analysis Chemically sulfated polysaccharide Factor Xa - metabolism Factor XII - metabolism Female Hemophilia A - physiopathology Humans Hydrocarbons, Iodinated - chemistry Mannans - chemistry Mannans - pharmacology Methylation Platelet Aggregation - drug effects Procoagulant effect Rats Rats, Wistar Sulfates - chemistry Thrombin - metabolism Venous Thrombosis - physiopathology
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