Self-assembled drug delivery systems. Part 8: In vitro/in vivo studies of the nanoassemblies of cholesteryl-phosphonyl gemcitabine

[Display omitted] A lipid derivative of gemcitabine (Gem), cholesteryl-phosphonyl gemcitabine (CPNG) was synthesized in this study. The amphiphilicity of CPNG was confirmed using a Langmuir monolayer method. Nanoassemblies were formed when the mixture of CPNG and a long-circulating material, CHS-PEG...

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Veröffentlicht in:	International journal of pharmaceutics 2015-01, Vol.478 (1), p.124-130
Hauptverfasser:	Li, Miao, Qi, Shuo, Jin, Yiguang, Dong, Junxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - chemistry Antimetabolites, Antineoplastic - pharmacokinetics Antimetabolites, Antineoplastic - therapeutic use Cell Line, Tumor Cell Survival - drug effects Cholesterol - administration & dosage Cholesterol - analogs & derivatives Cholesterol - chemistry Cholesterol - pharmacokinetics Cholesterol - therapeutic use Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - pharmacokinetics Deoxycytidine - therapeutic use Drug Delivery Systems Gemcitabine Humans Mice Molecular self-assembly Nanoassemblies Nanostructures - administration & dosage Nanostructures - chemistry Nanostructures - therapeutic use Neoplasms - drug therapy Neoplasms - pathology Phosphonate Prodrug Tumor Burden - drug effects
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