Pregnancy and Lupus Nephritis
Summary The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers. Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such...
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| Veröffentlicht in: | Seminars in nephrology 2015-09, Vol.35 (5), p.487-499 |
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| container_title | Seminars in nephrology |
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| creator | Kattah, Andrea G., MD Garovic, Vesna D., MD |
| description | Summary The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers. Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such as preeclampsia, fetal loss, and preterm delivery. Conception should be delayed until disease is in remission to ensure the best pregnancy outcomes. Maternal disease activity and fetal well-being should be monitored closely by an interdisciplinary team, including obstetricians, rheumatologists, and nephrologists throughout pregnancy. Careful attention must be paid to the dosing and potential teratogenicity of medications. |
| doi_str_mv | 10.1016/j.semnephrol.2015.08.010 |
| format | Article |
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Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such as preeclampsia, fetal loss, and preterm delivery. Conception should be delayed until disease is in remission to ensure the best pregnancy outcomes. Maternal disease activity and fetal well-being should be monitored closely by an interdisciplinary team, including obstetricians, rheumatologists, and nephrologists throughout pregnancy. Careful attention must be paid to the dosing and potential teratogenicity of medications.</description><identifier>ISSN: 0270-9295</identifier><identifier>EISSN: 1558-4488</identifier><identifier>DOI: 10.1016/j.semnephrol.2015.08.010</identifier><identifier>PMID: 26573551</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abortion, Spontaneous - epidemiology ; anti-inflammatory agents/therapeutic use ; Anticoagulants - therapeutic use ; Antihypertensive Agents - therapeutic use ; Antiphospholipid Syndrome - drug therapy ; Antiphospholipid Syndrome - epidemiology ; Antiphospholipid Syndrome - immunology ; Aspirin - therapeutic use ; Disease Progression ; Female ; Fibrinolytic Agents - therapeutic use ; Humans ; Hypertension - drug therapy ; Immunosuppressive Agents - therapeutic use ; Kidney - immunology ; Kidney - physiology ; Lupus Erythematosus, Systemic - drug therapy ; Lupus Erythematosus, Systemic - epidemiology ; Lupus Erythematosus, Systemic - immunology ; lupus nephritis ; Lupus Nephritis - drug therapy ; Lupus Nephritis - epidemiology ; Lupus Nephritis - immunology ; Nephrology ; Pre-Eclampsia - epidemiology ; preeclampsia ; Pregnancy ; Pregnancy - immunology ; Pregnancy - physiology ; pregnancy complications ; Pregnancy Complications - drug therapy ; Pregnancy Complications - epidemiology ; Pregnancy Complications - immunology ; Pregnancy Outcome ; Premature Birth - epidemiology ; Risk Factors ; systemic lupus erythematosus</subject><ispartof>Seminars in nephrology, 2015-09, Vol.35 (5), p.487-499</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-49a96d8390e1590d7c29d49d987fafa09042da5cc1ddf872895d981bb87202d23</citedby><cites>FETCH-LOGICAL-c429t-49a96d8390e1590d7c29d49d987fafa09042da5cc1ddf872895d981bb87202d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.semnephrol.2015.08.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26573551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kattah, Andrea G., MD</creatorcontrib><creatorcontrib>Garovic, Vesna D., MD</creatorcontrib><title>Pregnancy and Lupus Nephritis</title><title>Seminars in nephrology</title><addtitle>Semin Nephrol</addtitle><description>Summary The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers. Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such as preeclampsia, fetal loss, and preterm delivery. Conception should be delayed until disease is in remission to ensure the best pregnancy outcomes. Maternal disease activity and fetal well-being should be monitored closely by an interdisciplinary team, including obstetricians, rheumatologists, and nephrologists throughout pregnancy. Careful attention must be paid to the dosing and potential teratogenicity of medications.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>anti-inflammatory agents/therapeutic use</subject><subject>Anticoagulants - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antiphospholipid Syndrome - drug therapy</subject><subject>Antiphospholipid Syndrome - epidemiology</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Aspirin - therapeutic use</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney - immunology</subject><subject>Kidney - physiology</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>lupus nephritis</subject><subject>Lupus Nephritis - drug therapy</subject><subject>Lupus Nephritis - epidemiology</subject><subject>Lupus Nephritis - immunology</subject><subject>Nephrology</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy - immunology</subject><subject>Pregnancy - physiology</subject><subject>pregnancy complications</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Complications - immunology</subject><subject>Pregnancy Outcome</subject><subject>Premature Birth - epidemiology</subject><subject>Risk Factors</subject><subject>systemic lupus erythematosus</subject><issn>0270-9295</issn><issn>1558-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOwzAQRS0EgvL4BFCXbBJmnLixN0hQ8ZIqQALWlmtPwCVNit0g9e9JKA-JFasZae69oznD2BAhRcDRySyNNK9p8RKaKuWAIgWZAsIGG6AQMslzKTfZAHgBieJK7LDdGGcAHAuO22yHj0SRCYEDdngf6Lk2tV0NTe2Gk3bRxuFtn-yXPu6zrdJUkQ6-6h57urx4HF8nk7urm_HZJLE5V8skV0aNnMwUEAoFrrBcuVw5JYvSlAYU5NwZYS06V8qCSyW6GU6nXQ_c8WyPHa9zF6F5ayku9dxHS1VlamraqLHIci5BIHRSuZba0MQYqNSL4OcmrDSC7uHomf6Fo3s4GqSGT-vR15Z2Oif3Y_ym0QnO1wLqbn33FHS0nmpLzgeyS-0a_58tp39CbOVrb031SiuKs6YNdcdSo45cg37on9T_CAUA5lJkH7s_jbs</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Kattah, Andrea G., MD</creator><creator>Garovic, Vesna D., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Pregnancy and Lupus Nephritis</title><author>Kattah, Andrea G., MD ; Garovic, Vesna D., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-49a96d8390e1590d7c29d49d987fafa09042da5cc1ddf872895d981bb87202d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>anti-inflammatory agents/therapeutic use</topic><topic>Anticoagulants - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antiphospholipid Syndrome - drug therapy</topic><topic>Antiphospholipid Syndrome - epidemiology</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Aspirin - therapeutic use</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney - immunology</topic><topic>Kidney - physiology</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>lupus nephritis</topic><topic>Lupus Nephritis - drug therapy</topic><topic>Lupus Nephritis - epidemiology</topic><topic>Lupus Nephritis - immunology</topic><topic>Nephrology</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy - immunology</topic><topic>Pregnancy - physiology</topic><topic>pregnancy complications</topic><topic>Pregnancy Complications - drug therapy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Complications - immunology</topic><topic>Pregnancy Outcome</topic><topic>Premature Birth - epidemiology</topic><topic>Risk Factors</topic><topic>systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kattah, Andrea G., MD</creatorcontrib><creatorcontrib>Garovic, Vesna D., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kattah, Andrea G., MD</au><au>Garovic, Vesna D., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy and Lupus Nephritis</atitle><jtitle>Seminars in nephrology</jtitle><addtitle>Semin Nephrol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>35</volume><issue>5</issue><spage>487</spage><epage>499</epage><pages>487-499</pages><issn>0270-9295</issn><eissn>1558-4488</eissn><abstract>Summary The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers. Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such as preeclampsia, fetal loss, and preterm delivery. Conception should be delayed until disease is in remission to ensure the best pregnancy outcomes. Maternal disease activity and fetal well-being should be monitored closely by an interdisciplinary team, including obstetricians, rheumatologists, and nephrologists throughout pregnancy. Careful attention must be paid to the dosing and potential teratogenicity of medications.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26573551</pmid><doi>10.1016/j.semnephrol.2015.08.010</doi><tpages>13</tpages></addata></record> |
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| ispartof | Seminars in nephrology, 2015-09, Vol.35 (5), p.487-499 |
| issn | 0270-9295 1558-4488 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abortion, Spontaneous - epidemiology anti-inflammatory agents/therapeutic use Anticoagulants - therapeutic use Antihypertensive Agents - therapeutic use Antiphospholipid Syndrome - drug therapy Antiphospholipid Syndrome - epidemiology Antiphospholipid Syndrome - immunology Aspirin - therapeutic use Disease Progression Female Fibrinolytic Agents - therapeutic use Humans Hypertension - drug therapy Immunosuppressive Agents - therapeutic use Kidney - immunology Kidney - physiology Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - immunology lupus nephritis Lupus Nephritis - drug therapy Lupus Nephritis - epidemiology Lupus Nephritis - immunology Nephrology Pre-Eclampsia - epidemiology preeclampsia Pregnancy Pregnancy - immunology Pregnancy - physiology pregnancy complications Pregnancy Complications - drug therapy Pregnancy Complications - epidemiology Pregnancy Complications - immunology Pregnancy Outcome Premature Birth - epidemiology Risk Factors systemic lupus erythematosus |
| title | Pregnancy and Lupus Nephritis |
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