Neutrophils, Dendritic Cells, Toll-Like Receptors, and Interferon-α in Lupus Nephritis
Summary Finding better treatments for lupus nephritis requires an understanding of the pathogenesis of the causative systemic disease, how this leads to kidney disease, and how lupus nephritis progresses to end-stage kidney disease. Here, we provide a brief conceptual overview on the related pathome...
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| Veröffentlicht in: | Seminars in nephrology 2015-09, Vol.35 (5), p.410-426 |
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| container_title | Seminars in nephrology |
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| creator | Lorenz, Georg, MD Anders, Hans-Joachim, MD |
| description | Summary Finding better treatments for lupus nephritis requires an understanding of the pathogenesis of the causative systemic disease, how this leads to kidney disease, and how lupus nephritis progresses to end-stage kidney disease. Here, we provide a brief conceptual overview on the related pathomechanisms. As a main focus we discuss in detail the roles of neutrophils, dendritic cells, Toll-like receptors, and interferon-α in the pathogenesis of lupus nephritis by separately reviewing their roles in extrarenal systemic autoimmunity and in intrarenal inflammation and immunopathology. |
| doi_str_mv | 10.1016/j.semnephrol.2015.08.003 |
| format | Article |
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Here, we provide a brief conceptual overview on the related pathomechanisms. As a main focus we discuss in detail the roles of neutrophils, dendritic cells, Toll-like receptors, and interferon-α in the pathogenesis of lupus nephritis by separately reviewing their roles in extrarenal systemic autoimmunity and in intrarenal inflammation and immunopathology.</description><identifier>ISSN: 0270-9295</identifier><identifier>EISSN: 1558-4488</identifier><identifier>DOI: 10.1016/j.semnephrol.2015.08.003</identifier><identifier>PMID: 26573544</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptive Immunity - immunology ; Antigen-Antibody Complex - immunology ; antiviral ; Autoantibodies - immunology ; Autoantigens - immunology ; Dendritic Cells - immunology ; Extracellular Traps - immunology ; glomerulonephritis ; Humans ; Immune complex ; Immunity, Innate - immunology ; innate immunity ; Interferon-alpha - immunology ; Lupus Erythematosus, Systemic - immunology ; Lupus Nephritis - immunology ; Nephrology ; Neutrophils - immunology ; therapy ; Toll-Like Receptors - immunology</subject><ispartof>Seminars in nephrology, 2015-09, Vol.35 (5), p.410-426</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. 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Here, we provide a brief conceptual overview on the related pathomechanisms. As a main focus we discuss in detail the roles of neutrophils, dendritic cells, Toll-like receptors, and interferon-α in the pathogenesis of lupus nephritis by separately reviewing their roles in extrarenal systemic autoimmunity and in intrarenal inflammation and immunopathology.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26573544</pmid><doi>10.1016/j.semnephrol.2015.08.003</doi><tpages>17</tpages></addata></record> |
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| ispartof | Seminars in nephrology, 2015-09, Vol.35 (5), p.410-426 |
| issn | 0270-9295 1558-4488 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptive Immunity - immunology Antigen-Antibody Complex - immunology antiviral Autoantibodies - immunology Autoantigens - immunology Dendritic Cells - immunology Extracellular Traps - immunology glomerulonephritis Humans Immune complex Immunity, Innate - immunology innate immunity Interferon-alpha - immunology Lupus Erythematosus, Systemic - immunology Lupus Nephritis - immunology Nephrology Neutrophils - immunology therapy Toll-Like Receptors - immunology |
| title | Neutrophils, Dendritic Cells, Toll-Like Receptors, and Interferon-α in Lupus Nephritis |
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