SOCS3 is essential in the regulation of fetal liver erythropoiesis
SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene-mediated exp...
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| Veröffentlicht in: | Cell 1999-09, Vol.98 (5), p.617-627 |
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| container_title | Cell |
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| creator | Marine, J C McKay, C Wang, D Topham, D J Parganas, E Nakajima, H Pendeville, H Yasukawa, H Sasaki, A Yoshimura, A Ihle, J N |
| description | SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene-mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis. |
| doi_str_mv | 10.1016/s0092-8674(00)80049-5 |
| format | Article |
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During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene-mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.</description><identifier>ISSN: 0092-8674</identifier><identifier>DOI: 10.1016/s0092-8674(00)80049-5</identifier><identifier>PMID: 10490101</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Dose-Response Relationship, Drug ; Erythropoiesis - physiology ; Flow Cytometry ; Gene Expression Regulation, Developmental ; Hematopoiesis - physiology ; In Situ Hybridization ; Interleukin-2 - pharmacology ; Interleukin-4 - pharmacology ; Liver - embryology ; Liver - physiology ; Mice ; Mice, Mutant Strains ; Models, Genetic ; Mutagenesis ; Phenotype ; Proteins - genetics ; Proteins - physiology ; Repressor Proteins ; Suppressor of Cytokine Signaling 3 Protein ; Suppressor of Cytokine Signaling Proteins ; Time Factors ; Transcription Factors ; Transfection</subject><ispartof>Cell, 1999-09, Vol.98 (5), p.617-627</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-6a2fce4680ae0e05da1a24b8fa44b3d67d48407129210edf25b6fae684ee4f733</citedby><cites>FETCH-LOGICAL-c449t-6a2fce4680ae0e05da1a24b8fa44b3d67d48407129210edf25b6fae684ee4f733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10490101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marine, J C</creatorcontrib><creatorcontrib>McKay, C</creatorcontrib><creatorcontrib>Wang, D</creatorcontrib><creatorcontrib>Topham, D J</creatorcontrib><creatorcontrib>Parganas, E</creatorcontrib><creatorcontrib>Nakajima, H</creatorcontrib><creatorcontrib>Pendeville, H</creatorcontrib><creatorcontrib>Yasukawa, H</creatorcontrib><creatorcontrib>Sasaki, A</creatorcontrib><creatorcontrib>Yoshimura, A</creatorcontrib><creatorcontrib>Ihle, J N</creatorcontrib><title>SOCS3 is essential in the regulation of fetal liver erythropoiesis</title><title>Cell</title><addtitle>Cell</addtitle><description>SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene-mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.</description><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erythropoiesis - physiology</subject><subject>Flow Cytometry</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hematopoiesis - physiology</subject><subject>In Situ Hybridization</subject><subject>Interleukin-2 - pharmacology</subject><subject>Interleukin-4 - pharmacology</subject><subject>Liver - embryology</subject><subject>Liver - physiology</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Models, Genetic</subject><subject>Mutagenesis</subject><subject>Phenotype</subject><subject>Proteins - genetics</subject><subject>Proteins - physiology</subject><subject>Repressor Proteins</subject><subject>Suppressor of Cytokine Signaling 3 Protein</subject><subject>Suppressor of Cytokine Signaling Proteins</subject><subject>Time Factors</subject><subject>Transcription Factors</subject><subject>Transfection</subject><issn>0092-8674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRb0A0VL4BJBXCBaBcWI7yRIiXlKlLgpry0nG1CiNi-0g9e9JaYVYjXTn3BnpEHLB4JYBk3cBoEyTQub8GuCmAOBlIo7I9C-ekNMQPgGgEEKckAkbCRirU_KwXFTLjNpAMQTso9UdtT2NK6QeP4ZOR-t66gw1GMdVZ7_RU_TbuPJu4ywGG87IsdFdwPPDnJH3p8e36iWZL55fq_t50nBexkTq1DTIZQEaAUG0mumU14XRnNdZK_OWFxxylpYpA2xNKmppNMqCI3KTZ9mMXO3vbrz7GjBEtbahwa7TPbohKJZnnLE0H0GxBxvvQvBo1MbbtfZbxUDthKnlzozamVEA6leYEmPv8vBgqNfY_mvtbWU_PAFoWg</recordid><startdate>19990903</startdate><enddate>19990903</enddate><creator>Marine, J C</creator><creator>McKay, C</creator><creator>Wang, D</creator><creator>Topham, D J</creator><creator>Parganas, E</creator><creator>Nakajima, H</creator><creator>Pendeville, H</creator><creator>Yasukawa, H</creator><creator>Sasaki, A</creator><creator>Yoshimura, A</creator><creator>Ihle, J N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19990903</creationdate><title>SOCS3 is essential in the regulation of fetal liver erythropoiesis</title><author>Marine, J C ; 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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Dose-Response Relationship, Drug Erythropoiesis - physiology Flow Cytometry Gene Expression Regulation, Developmental Hematopoiesis - physiology In Situ Hybridization Interleukin-2 - pharmacology Interleukin-4 - pharmacology Liver - embryology Liver - physiology Mice Mice, Mutant Strains Models, Genetic Mutagenesis Phenotype Proteins - genetics Proteins - physiology Repressor Proteins Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Time Factors Transcription Factors Transfection |
| title | SOCS3 is essential in the regulation of fetal liver erythropoiesis |
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