The pathogenic potential of endogenous retroviruses: facts and fantasies
Endogenous retroviruses are descendants of viruses that became cellular genes by integration into their host’s genome. They still contribute to pathogenicity as a partner in recombination events, by de novo insertion after mobilization followed by activation of downstream proto-oncogenes, or by gene...
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| Veröffentlicht in: | Trends in Microbiology 1999-09, Vol.7 (9), p.350-356 |
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| container_title | Trends in Microbiology |
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| creator | Loewer, R |
| description | Endogenous retroviruses are descendants of viruses that became cellular genes by integration into their host’s genome. They still contribute to pathogenicity as a partner in recombination events, by
de novo insertion after mobilization followed by activation of downstream proto-oncogenes, or by gene disruption. Re-expression of viral proteins accompanied by loss of immune tolerance could induce immune disturbances. |
| doi_str_mv | 10.1016/S0966-842X(99)01565-6 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Trends in Microbiology, 1999-09, Vol.7 (9), p.350-356 |
| issn | 0966-842X 1878-4380 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Autoimmune disease Co-suppression Endogenous retrovirus Endogenous Retroviruses - genetics Endogenous Retroviruses - pathogenicity Gene Deletion HTDV/HERV-K Humans Insertion mutagenesis Mutagenesis, Insertional Rats Recombination Recombination, Genetic Retroviridae Retroviridae Infections - virology Virulence |
| title | The pathogenic potential of endogenous retroviruses: facts and fantasies |
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