Redundant Intronic Repressors Function to Inhibit Fibroblast Growth Factor Receptor-1 α-Exon Recognition in Glioblastoma Cells

The human fibroblast growth factor receptor-1 primary transcript is alternatively processed to produce receptor forms that vary in their affinity for fibroblast growth factor. The inclusion of a single exon (α) in normal brain glial cells produces a low affinity form of the receptor. Recognition of...

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Veröffentlicht in:	The Journal of biological chemistry 1999-09, Vol.274 (39), p.28035-28041
Hauptverfasser:	Jin, Wei, Huang, Eileen S.-C., Bi, Weiqi, Cote, Gilbert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Base Sequence DNA Primers Exons Fibroblast Growth Factors - metabolism Glioblastoma - genetics Humans Introns Molecular Sequence Data Rats Receptor Protein-Tyrosine Kinases - genetics Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - genetics Recombinant Proteins - biosynthesis Repressor Proteins - metabolism Sequence Deletion Transcription, Genetic Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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