Imaging addiction with PET: is insight in sight?
PET investigations of pathology underlying drug abuse, dependence and addiction have provided target mechanisms through which medications might ameliorate these conditions. This deeper understanding should facilitate the reformulation of a complex and clearly transitional nosology. Neurochemical ima...
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| Veröffentlicht in: | Drug Discovery Today 2005-04, Vol.10 (8), p.547-562 |
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| creator | Schiffer, Wynne K. Lee, Dianne E. Brodie, Jonathan D. Dewey, Stephen L. |
| description | PET investigations of pathology underlying drug abuse, dependence and addiction have provided target mechanisms through which medications might ameliorate these conditions. This deeper understanding should facilitate the reformulation of a complex and clearly transitional nosology.
Neurochemical imaging studies can identify molecular targets of abused drugs and link them to the underlying pathology associated with behaviors such as drug dependence, addiction and withdrawal. positron emission tomography (PET) is opening new avenues for the investigation of the neurochemical disturbances underlying drug abuse and addiction and the
in vivo mechanisms by which medications might ameliorate these conditions. PET can identify vulnerable human populations, treatment strategies and monitor treatment efficacy. Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand. |
| doi_str_mv | 10.1016/S1359-6446(05)03412-4 |
| format | Article |
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Neurochemical imaging studies can identify molecular targets of abused drugs and link them to the underlying pathology associated with behaviors such as drug dependence, addiction and withdrawal. positron emission tomography (PET) is opening new avenues for the investigation of the neurochemical disturbances underlying drug abuse and addiction and the
in vivo mechanisms by which medications might ameliorate these conditions. PET can identify vulnerable human populations, treatment strategies and monitor treatment efficacy. Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>dependence</subject><subject>Forecasting</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>neuroimaging</subject><subject>neurotransmitter interactions</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>pharmacotherapy</subject><subject>Positron-Emission Tomography - instrumentation</subject><subject>Positron-Emission Tomography - trends</subject><subject>Positron-Emission Tomography - utilization</subject><subject>relapse</subject><subject>Substance-Related Disorders - diagnosis</subject><subject>Terminology as Topic</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LwzAYx4Mobk4_gtKLoodq0rw1XoaMqYOBgvMc0iTdIl07k07x25ttlR29PP_n8Hte-AFwjuAtgojdvSFMRcoIYdeQ3kBMUJaSA9BHOc9TmuPsMPZ_SA-chPABIcoEZceghyLAqcj7AE6Wau7qeaKMcbp1TZ18u3aRvI5n94kLiauDmy_amMm2GZ6Co1JVwZ51OQDvj-PZ6DmdvjxNRg_TVBMi2lhRCaEuoKVUG8I4xYVggmcQUo6YwgQynhHMlRDaYEoNQiY3BAmYWVLkeACudntXvvlc29DKpQvaVpWqbbMOEnGMedwYQboDtW9C8LaUK--Wyv9IBOVGldyqkhsPElK5VSVJnLvoDqyLpTX7qc5NBC47QAWtqtKrWruw5xjDKKM4csMdZ6OOL2e9DNrZWlvjvNWtNI3755VfE06CCg</recordid><startdate>20050415</startdate><enddate>20050415</enddate><creator>Schiffer, Wynne K.</creator><creator>Lee, Dianne E.</creator><creator>Brodie, Jonathan D.</creator><creator>Dewey, Stephen L.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20050415</creationdate><title>Imaging addiction with PET: is insight in sight?</title><author>Schiffer, Wynne K. ; Lee, Dianne E. ; Brodie, Jonathan D. ; Dewey, Stephen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-c41f00cb0e55cd46753b96972005716a340672437a99cd355d11d8d41902e4b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>dependence</topic><topic>Forecasting</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>neuroimaging</topic><topic>neurotransmitter interactions</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>pharmacotherapy</topic><topic>Positron-Emission Tomography - instrumentation</topic><topic>Positron-Emission Tomography - trends</topic><topic>Positron-Emission Tomography - utilization</topic><topic>relapse</topic><topic>Substance-Related Disorders - diagnosis</topic><topic>Terminology as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiffer, Wynne K.</creatorcontrib><creatorcontrib>Lee, Dianne E.</creatorcontrib><creatorcontrib>Brodie, Jonathan D.</creatorcontrib><creatorcontrib>Dewey, Stephen L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Drug Discovery Today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiffer, Wynne K.</au><au>Lee, Dianne E.</au><au>Brodie, Jonathan D.</au><au>Dewey, Stephen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging addiction with PET: is insight in sight?</atitle><jtitle>Drug Discovery Today</jtitle><addtitle>Drug Discov Today</addtitle><date>2005-04-15</date><risdate>2005</risdate><volume>10</volume><issue>8</issue><spage>547</spage><epage>562</epage><pages>547-562</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>PET investigations of pathology underlying drug abuse, dependence and addiction have provided target mechanisms through which medications might ameliorate these conditions. 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Neurochemical imaging studies can identify molecular targets of abused drugs and link them to the underlying pathology associated with behaviors such as drug dependence, addiction and withdrawal. positron emission tomography (PET) is opening new avenues for the investigation of the neurochemical disturbances underlying drug abuse and addiction and the
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| subjects | Animals Biological and medical sciences dependence Forecasting General pharmacology Humans Medical sciences neuroimaging neurotransmitter interactions Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments pharmacotherapy Positron-Emission Tomography - instrumentation Positron-Emission Tomography - trends Positron-Emission Tomography - utilization relapse Substance-Related Disorders - diagnosis Terminology as Topic |
| title | Imaging addiction with PET: is insight in sight? |
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