FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma

Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinom...

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Veröffentlicht in:	Pathobiology (Basel) 2015-01, Vol.82 (6), p.280-289
Hauptverfasser:	Koole, Koos, van Kempen, Pauline M.W., van Bockel, Liselotte W., Smets, Timo, van der Klooster, Zoë, Dutman, Annemiek C., Peeters, Ton, Koole, Ron, van Diest, Paul, van Es, Robert J.J., Willems, Stefan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - radiotherapy Female Genotype Genotypes Growth factors Humans Immunohistochemistry Male Middle Aged Mouth Neoplasms - diagnosis Mouth Neoplasms - genetics Mouth Neoplasms - radiotherapy Oral cancer Original Paper Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - genetics Oropharyngeal Neoplasms - radiotherapy Polymerase Chain Reaction Polymorphism, Genetic Prognosis Receptor, Fibroblast Growth Factor, Type 4 - genetics Receptor, Fibroblast Growth Factor, Type 4 - metabolism Sequence Analysis, DNA Throat cancer Tissue Array Analysis Up-Regulation
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