FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma
Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinom...
Gespeichert in:
| Veröffentlicht in: | Pathobiology (Basel) 2015-01, Vol.82 (6), p.280-289 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 289 |
|---|---|
| container_issue | 6 |
| container_start_page | 280 |
| container_title | Pathobiology (Basel) |
| container_volume | 82 |
| creator | Koole, Koos van Kempen, Pauline M.W. van Bockel, Liselotte W. Smets, Timo van der Klooster, Zoë Dutman, Annemiek C. Peeters, Ton Koole, Ron van Diest, Paul van Es, Robert J.J. Willems, Stefan M. |
| description | Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC). Methods: FGFR4 immunohistochemistry and FGFR4/CEN5q FISH were performed on tissue microarrays from 212 OSCC and 238 OPSCC patients. FGFR4 genotypes were determined by PCR and DNA sequencing in 76 random OPSCC samples. The response to radiotherapy was evaluated 3 months after the last radiotherapy treatment session by a head and neck radiation oncologist and/or surgeon during clinic visits. The results were correlated to overall survival and response to radiotherapy. Results: The FGFR4 protein was overexpressed in 64% (153/238) of OPSCCs and 41% (87/212) of OSCCs. The FGFR4 gene was amplified in 0.47% (1/212) of OSCCs and 0.42% (1/238) of OPSCCs, and the FGFR4 Gly388Arg polymorphism was detected in 62% (47/76) of OPSCCs. FGFR4 protein expression, FGFR4 gene copy numbers and FGFR4 genotypes were not related to overall survival or response to radiotherapy in OSCC or OPSCC. Conclusion: FGFR4 is frequently overexpressed in OSCC and OPSCC in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC. |
| doi_str_mv | 10.1159/000439536 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_proquest_miscellaneous_1733194488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3916770141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c334t-934d5899376059994712671d875f1f28cfee8102fd5e41c00b3ba7fca31808863</originalsourceid><addsrcrecordid>eNpdkL1PwzAQxS0EoqUwsCNkiQWGwDm2E3uEiJZKlVrxMTFEbuIUl3y0doLU_x5XLR2Y7unud09PD6FLAveEcPkAAIxKTqMj1CcspAGEkhx7DYQHIYDooTPnlh4TEMEp6oUR54QL3kefw9HwleGxwwrPmlbXrVElnlmdm6w1Pxo_maZS9ltbbGo8tf6o6tyLZvWl7KZeaL95W3eqajqHE12WOFE2M7X_OkcnhSqdvtjPAfoYPr8nL8FkOhonj5Mgo5S1gaQs50JKGkfApZQsJmEUk1zEvCBFKLJCa0EgLHKuGckA5nSu4iJTlAgQIqIDdLvzXdlm3WnXppVxmY-iau1TpSSmlEjGhPDozT902XS29uk8xTlnPI62hnc7KrONc1YX6coa38ImJZBuG08PjXv2eu_YzSudH8i_ij1wtQO-lV1oewD2_79Hq4De</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1755545766</pqid></control><display><type>article</type><title>FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>Karger Journals Complete</source><creator>Koole, Koos ; van Kempen, Pauline M.W. ; van Bockel, Liselotte W. ; Smets, Timo ; van der Klooster, Zoë ; Dutman, Annemiek C. ; Peeters, Ton ; Koole, Ron ; van Diest, Paul ; van Es, Robert J.J. ; Willems, Stefan M.</creator><creatorcontrib>Koole, Koos ; van Kempen, Pauline M.W. ; van Bockel, Liselotte W. ; Smets, Timo ; van der Klooster, Zoë ; Dutman, Annemiek C. ; Peeters, Ton ; Koole, Ron ; van Diest, Paul ; van Es, Robert J.J. ; Willems, Stefan M.</creatorcontrib><description>Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC). Methods: FGFR4 immunohistochemistry and FGFR4/CEN5q FISH were performed on tissue microarrays from 212 OSCC and 238 OPSCC patients. FGFR4 genotypes were determined by PCR and DNA sequencing in 76 random OPSCC samples. The response to radiotherapy was evaluated 3 months after the last radiotherapy treatment session by a head and neck radiation oncologist and/or surgeon during clinic visits. The results were correlated to overall survival and response to radiotherapy. Results: The FGFR4 protein was overexpressed in 64% (153/238) of OPSCCs and 41% (87/212) of OSCCs. The FGFR4 gene was amplified in 0.47% (1/212) of OSCCs and 0.42% (1/238) of OPSCCs, and the FGFR4 Gly388Arg polymorphism was detected in 62% (47/76) of OPSCCs. FGFR4 protein expression, FGFR4 gene copy numbers and FGFR4 genotypes were not related to overall survival or response to radiotherapy in OSCC or OPSCC. Conclusion: FGFR4 is frequently overexpressed in OSCC and OPSCC in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC.</description><identifier>ISSN: 1015-2008</identifier><identifier>EISSN: 1423-0291</identifier><identifier>DOI: 10.1159/000439536</identifier><identifier>PMID: 26551585</identifier><identifier>CODEN: PATHEF</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - radiotherapy ; Female ; Genotype ; Genotypes ; Growth factors ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - genetics ; Mouth Neoplasms - radiotherapy ; Oral cancer ; Original Paper ; Oropharyngeal Neoplasms - diagnosis ; Oropharyngeal Neoplasms - genetics ; Oropharyngeal Neoplasms - radiotherapy ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Prognosis ; Receptor, Fibroblast Growth Factor, Type 4 - genetics ; Receptor, Fibroblast Growth Factor, Type 4 - metabolism ; Sequence Analysis, DNA ; Throat cancer ; Tissue Array Analysis ; Up-Regulation</subject><ispartof>Pathobiology (Basel), 2015-01, Vol.82 (6), p.280-289</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><rights>Copyright S. Karger AG Nov 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-934d5899376059994712671d875f1f28cfee8102fd5e41c00b3ba7fca31808863</citedby><cites>FETCH-LOGICAL-c334t-934d5899376059994712671d875f1f28cfee8102fd5e41c00b3ba7fca31808863</cites><orcidid>0000-0001-7516-5270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26551585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koole, Koos</creatorcontrib><creatorcontrib>van Kempen, Pauline M.W.</creatorcontrib><creatorcontrib>van Bockel, Liselotte W.</creatorcontrib><creatorcontrib>Smets, Timo</creatorcontrib><creatorcontrib>van der Klooster, Zoë</creatorcontrib><creatorcontrib>Dutman, Annemiek C.</creatorcontrib><creatorcontrib>Peeters, Ton</creatorcontrib><creatorcontrib>Koole, Ron</creatorcontrib><creatorcontrib>van Diest, Paul</creatorcontrib><creatorcontrib>van Es, Robert J.J.</creatorcontrib><creatorcontrib>Willems, Stefan M.</creatorcontrib><title>FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma</title><title>Pathobiology (Basel)</title><addtitle>Pathobiology</addtitle><description>Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC). Methods: FGFR4 immunohistochemistry and FGFR4/CEN5q FISH were performed on tissue microarrays from 212 OSCC and 238 OPSCC patients. FGFR4 genotypes were determined by PCR and DNA sequencing in 76 random OPSCC samples. The response to radiotherapy was evaluated 3 months after the last radiotherapy treatment session by a head and neck radiation oncologist and/or surgeon during clinic visits. The results were correlated to overall survival and response to radiotherapy. Results: The FGFR4 protein was overexpressed in 64% (153/238) of OPSCCs and 41% (87/212) of OSCCs. The FGFR4 gene was amplified in 0.47% (1/212) of OSCCs and 0.42% (1/238) of OPSCCs, and the FGFR4 Gly388Arg polymorphism was detected in 62% (47/76) of OPSCCs. FGFR4 protein expression, FGFR4 gene copy numbers and FGFR4 genotypes were not related to overall survival or response to radiotherapy in OSCC or OPSCC. Conclusion: FGFR4 is frequently overexpressed in OSCC and OPSCC in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - radiotherapy</subject><subject>Oral cancer</subject><subject>Original Paper</subject><subject>Oropharyngeal Neoplasms - diagnosis</subject><subject>Oropharyngeal Neoplasms - genetics</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Prognosis</subject><subject>Receptor, Fibroblast Growth Factor, Type 4 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 4 - metabolism</subject><subject>Sequence Analysis, DNA</subject><subject>Throat cancer</subject><subject>Tissue Array Analysis</subject><subject>Up-Regulation</subject><issn>1015-2008</issn><issn>1423-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkL1PwzAQxS0EoqUwsCNkiQWGwDm2E3uEiJZKlVrxMTFEbuIUl3y0doLU_x5XLR2Y7unud09PD6FLAveEcPkAAIxKTqMj1CcspAGEkhx7DYQHIYDooTPnlh4TEMEp6oUR54QL3kefw9HwleGxwwrPmlbXrVElnlmdm6w1Pxo_maZS9ltbbGo8tf6o6tyLZvWl7KZeaL95W3eqajqHE12WOFE2M7X_OkcnhSqdvtjPAfoYPr8nL8FkOhonj5Mgo5S1gaQs50JKGkfApZQsJmEUk1zEvCBFKLJCa0EgLHKuGckA5nSu4iJTlAgQIqIDdLvzXdlm3WnXppVxmY-iau1TpSSmlEjGhPDozT902XS29uk8xTlnPI62hnc7KrONc1YX6coa38ImJZBuG08PjXv2eu_YzSudH8i_ij1wtQO-lV1oewD2_79Hq4De</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Koole, Koos</creator><creator>van Kempen, Pauline M.W.</creator><creator>van Bockel, Liselotte W.</creator><creator>Smets, Timo</creator><creator>van der Klooster, Zoë</creator><creator>Dutman, Annemiek C.</creator><creator>Peeters, Ton</creator><creator>Koole, Ron</creator><creator>van Diest, Paul</creator><creator>van Es, Robert J.J.</creator><creator>Willems, Stefan M.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7516-5270</orcidid></search><sort><creationdate>20150101</creationdate><title>FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma</title><author>Koole, Koos ; van Kempen, Pauline M.W. ; van Bockel, Liselotte W. ; Smets, Timo ; van der Klooster, Zoë ; Dutman, Annemiek C. ; Peeters, Ton ; Koole, Ron ; van Diest, Paul ; van Es, Robert J.J. ; Willems, Stefan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-934d5899376059994712671d875f1f28cfee8102fd5e41c00b3ba7fca31808863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - radiotherapy</topic><topic>Oral cancer</topic><topic>Original Paper</topic><topic>Oropharyngeal Neoplasms - diagnosis</topic><topic>Oropharyngeal Neoplasms - genetics</topic><topic>Oropharyngeal Neoplasms - radiotherapy</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Prognosis</topic><topic>Receptor, Fibroblast Growth Factor, Type 4 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 4 - metabolism</topic><topic>Sequence Analysis, DNA</topic><topic>Throat cancer</topic><topic>Tissue Array Analysis</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koole, Koos</creatorcontrib><creatorcontrib>van Kempen, Pauline M.W.</creatorcontrib><creatorcontrib>van Bockel, Liselotte W.</creatorcontrib><creatorcontrib>Smets, Timo</creatorcontrib><creatorcontrib>van der Klooster, Zoë</creatorcontrib><creatorcontrib>Dutman, Annemiek C.</creatorcontrib><creatorcontrib>Peeters, Ton</creatorcontrib><creatorcontrib>Koole, Ron</creatorcontrib><creatorcontrib>van Diest, Paul</creatorcontrib><creatorcontrib>van Es, Robert J.J.</creatorcontrib><creatorcontrib>Willems, Stefan M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Pathobiology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koole, Koos</au><au>van Kempen, Pauline M.W.</au><au>van Bockel, Liselotte W.</au><au>Smets, Timo</au><au>van der Klooster, Zoë</au><au>Dutman, Annemiek C.</au><au>Peeters, Ton</au><au>Koole, Ron</au><au>van Diest, Paul</au><au>van Es, Robert J.J.</au><au>Willems, Stefan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma</atitle><jtitle>Pathobiology (Basel)</jtitle><addtitle>Pathobiology</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>82</volume><issue>6</issue><spage>280</spage><epage>289</epage><pages>280-289</pages><issn>1015-2008</issn><eissn>1423-0291</eissn><coden>PATHEF</coden><abstract>Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC). Methods: FGFR4 immunohistochemistry and FGFR4/CEN5q FISH were performed on tissue microarrays from 212 OSCC and 238 OPSCC patients. FGFR4 genotypes were determined by PCR and DNA sequencing in 76 random OPSCC samples. The response to radiotherapy was evaluated 3 months after the last radiotherapy treatment session by a head and neck radiation oncologist and/or surgeon during clinic visits. The results were correlated to overall survival and response to radiotherapy. Results: The FGFR4 protein was overexpressed in 64% (153/238) of OPSCCs and 41% (87/212) of OSCCs. The FGFR4 gene was amplified in 0.47% (1/212) of OSCCs and 0.42% (1/238) of OPSCCs, and the FGFR4 Gly388Arg polymorphism was detected in 62% (47/76) of OPSCCs. FGFR4 protein expression, FGFR4 gene copy numbers and FGFR4 genotypes were not related to overall survival or response to radiotherapy in OSCC or OPSCC. Conclusion: FGFR4 is frequently overexpressed in OSCC and OPSCC in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>26551585</pmid><doi>10.1159/000439536</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7516-5270</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1015-2008 |
| ispartof | Pathobiology (Basel), 2015-01, Vol.82 (6), p.280-289 |
| issn | 1015-2008 1423-0291 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1733194488 |
| source | MEDLINE; Karger Journals Complete |
| subjects | Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - radiotherapy Female Genotype Genotypes Growth factors Humans Immunohistochemistry Male Middle Aged Mouth Neoplasms - diagnosis Mouth Neoplasms - genetics Mouth Neoplasms - radiotherapy Oral cancer Original Paper Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - genetics Oropharyngeal Neoplasms - radiotherapy Polymerase Chain Reaction Polymorphism, Genetic Prognosis Receptor, Fibroblast Growth Factor, Type 4 - genetics Receptor, Fibroblast Growth Factor, Type 4 - metabolism Sequence Analysis, DNA Throat cancer Tissue Array Analysis Up-Regulation |
| title | FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A33%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=FGFR4%20Is%20a%20Potential%20Predictive%20Biomarker%20in%20Oral%20and%20Oropharyngeal%20Squamous%20Cell%20Carcinoma&rft.jtitle=Pathobiology%20(Basel)&rft.au=Koole,%20Koos&rft.date=2015-01-01&rft.volume=82&rft.issue=6&rft.spage=280&rft.epage=289&rft.pages=280-289&rft.issn=1015-2008&rft.eissn=1423-0291&rft.coden=PATHEF&rft_id=info:doi/10.1159/000439536&rft_dat=%3Cproquest_karge%3E3916770141%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1755545766&rft_id=info:pmid/26551585&rfr_iscdi=true |