Endothelial Hypoxia-Inducible Factor-1α Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a

Chemokines mediate monocyte adhesion to dysfunctional endothelial cells (ECs) and promote arterial inflammation during atherosclerosis. Hypoxia-inducible factor (HIF)-1α is expressed in various cell types of atherosclerotic lesions and is associated with lesional inflammation. However, the impact of...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-12, Vol.66 (6), p.1220-1226
Hauptverfasser:	Akhtar, Shamima, Hartmann, Petra, Karshovska, Ela, Rinderknecht, Fatuma-Ayaan, Subramanian, Pallavi, Gremse, Felix, Grommes, Jochen, Jacobs, Michael, Kiessling, Fabian, Weber, Christian, Steffens, Sabine, Schober, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - genetics Atherosclerosis - metabolism Blotting, Western Cell Adhesion - drug effects Cell Adhesion - genetics Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokine CXCL1 - genetics Chemokine CXCL1 - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Gene Expression - drug effects Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lipoproteins, LDL - pharmacology Mice, Knockout MicroRNAs - genetics Monocytes - metabolism Oligonucleotides, Antisense - genetics Reverse Transcriptase Polymerase Chain Reaction RNA Interference
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