A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart

To study the specification of inflow structures in the heart we generated transgenic animals harboring the human alkaline phosphatase (HAP) gene driven by the proximal 840 bp of a quail SMyHC3 promoter. In transgenic mice, the SMyHC3-HAP reporter was expressed in posterior heart precursors at 8.25 d...

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Veröffentlicht in:	Development (Cambridge) 1999-06, Vol.126 (12), p.2677-2687
Hauptverfasser:	Xavier-Neto, J, Neville, C M, Shapiro, M D, Houghton, L, Wang, G F, Nikovits, Jr, W, Stockdale, F E, Rosenthal, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - drug effects Alkaline Phosphatase - genetics Animals Disulfiram - pharmacology Enzyme Inhibitors - pharmacology Female Gene Expression Regulation, Developmental - drug effects Genetic Markers Heart - embryology Heart Atria - embryology Heart Atria - metabolism Heart Defects, Congenital - chemically induced Heart Defects, Congenital - genetics Heart Ventricles - embryology Heart Ventricles - metabolism Humans Mice Mice, Transgenic Pregnancy Promoter Regions, Genetic Response Elements Signal Transduction Transcription, Genetic Transgenes Tretinoin - metabolism Tretinoin - pharmacology
Online-Zugang:	Volltext
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