TRP Channels in Insect Stretch Receptors as Insecticide Targets
Defining the molecular targets of insecticides is crucial for assessing their selectivity and potential impact on environment and health. Two commercial insecticides are now shown to target a transient receptor potential (TRP) ion channel complex that is unique to insect stretch receptor cells. Pyme...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2015-05, Vol.86 (3), p.665-671 |
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| creator | Nesterov, Alexandre Spalthoff, Christian Kandasamy, Ramani Katana, Radoslav Rankl, Nancy B Andrés, Marta Jähde, Philipp Dorsch, John A Stam, Lynn F Braun, Franz-Josef Warren, Ben Salgado, Vincent L Göpfert, Martin C |
| description | Defining the molecular targets of insecticides is crucial for assessing their selectivity and potential impact on environment and health. Two commercial insecticides are now shown to target a transient receptor potential (TRP) ion channel complex that is unique to insect stretch receptor cells. Pymetrozine and pyrifluquinazon disturbed Drosophila coordination and hearing by acting on chordotonal stretch receptor neurons. This action required the two TRPs Nanchung (Nan) and Inactive (Iav), which co-occur exclusively within these cells. Nan and Iav together sufficed to confer cellular insecticide responses in vivo and in vitro, and the two insecticides were identified as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells. This establishes TRPs as insecticide targets and defines specific agonists of insect TRPs. It also shows that TRPs can render insecticides cell-type selective and puts forward TRP targets to reduce side effects on non-target species. |
| doi_str_mv | 10.1016/j.neuron.2015.04.001 |
| format | Article |
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Two commercial insecticides are now shown to target a transient receptor potential (TRP) ion channel complex that is unique to insect stretch receptor cells. Pymetrozine and pyrifluquinazon disturbed Drosophila coordination and hearing by acting on chordotonal stretch receptor neurons. This action required the two TRPs Nanchung (Nan) and Inactive (Iav), which co-occur exclusively within these cells. Nan and Iav together sufficed to confer cellular insecticide responses in vivo and in vitro, and the two insecticides were identified as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells. This establishes TRPs as insecticide targets and defines specific agonists of insect TRPs. It also shows that TRPs can render insecticides cell-type selective and puts forward TRP targets to reduce side effects on non-target species.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2015.04.001</identifier><identifier>PMID: 25950634</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Acoustic Stimulation ; Action Potentials - drug effects ; Action Potentials - genetics ; Animals ; Animals, Genetically Modified ; Arthropod Antennae - cytology ; Behavior ; CHO Cells ; Cricetulus ; Drosophila ; Drosophila Proteins - drug effects ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Evacuations & rescues ; Experiments ; Gravity Sensing - drug effects ; Gravity Sensing - genetics ; Insects ; Ion Channels - drug effects ; Ion Channels - genetics ; Ion Channels - metabolism ; Larva ; Mechanoreceptors - drug effects ; Mechanoreceptors - physiology ; Movement - drug effects ; Neurons - drug effects ; Pesticides - pharmacology ; Proteins ; Quinazolinones - pharmacology ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transient Receptor Potential Channels - drug effects ; Transient Receptor Potential Channels - genetics ; Triazines - pharmacology</subject><ispartof>Neuron (Cambridge, Mass.), 2015-05, Vol.86 (3), p.665-671</ispartof><rights>Copyright © 2015 Elsevier Inc. 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Spalthoff, Christian ; Kandasamy, Ramani ; Katana, Radoslav ; Rankl, Nancy B ; Andrés, Marta ; Jähde, Philipp ; Dorsch, John A ; Stam, Lynn F ; Braun, Franz-Josef ; Warren, Ben ; Salgado, Vincent L ; Göpfert, Martin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-af4aba54d3b8c9744cc7200f4d1774302b8c3456edad64b14457993c52882c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustic Stimulation</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - genetics</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Arthropod Antennae - cytology</topic><topic>Behavior</topic><topic>CHO Cells</topic><topic>Cricetulus</topic><topic>Drosophila</topic><topic>Drosophila Proteins - drug effects</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Evacuations & rescues</topic><topic>Experiments</topic><topic>Gravity Sensing - drug effects</topic><topic>Gravity Sensing - genetics</topic><topic>Insects</topic><topic>Ion Channels - drug effects</topic><topic>Ion Channels - genetics</topic><topic>Ion Channels - metabolism</topic><topic>Larva</topic><topic>Mechanoreceptors - drug effects</topic><topic>Mechanoreceptors - physiology</topic><topic>Movement - drug effects</topic><topic>Neurons - drug effects</topic><topic>Pesticides - pharmacology</topic><topic>Proteins</topic><topic>Quinazolinones - pharmacology</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transient Receptor Potential Channels - drug effects</topic><topic>Transient Receptor Potential Channels - genetics</topic><topic>Triazines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nesterov, Alexandre</creatorcontrib><creatorcontrib>Spalthoff, Christian</creatorcontrib><creatorcontrib>Kandasamy, Ramani</creatorcontrib><creatorcontrib>Katana, Radoslav</creatorcontrib><creatorcontrib>Rankl, Nancy B</creatorcontrib><creatorcontrib>Andrés, Marta</creatorcontrib><creatorcontrib>Jähde, Philipp</creatorcontrib><creatorcontrib>Dorsch, John A</creatorcontrib><creatorcontrib>Stam, Lynn F</creatorcontrib><creatorcontrib>Braun, Franz-Josef</creatorcontrib><creatorcontrib>Warren, Ben</creatorcontrib><creatorcontrib>Salgado, Vincent L</creatorcontrib><creatorcontrib>Göpfert, Martin C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nesterov, Alexandre</au><au>Spalthoff, Christian</au><au>Kandasamy, Ramani</au><au>Katana, Radoslav</au><au>Rankl, Nancy B</au><au>Andrés, Marta</au><au>Jähde, Philipp</au><au>Dorsch, John A</au><au>Stam, Lynn F</au><au>Braun, Franz-Josef</au><au>Warren, Ben</au><au>Salgado, Vincent L</au><au>Göpfert, Martin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRP Channels in Insect Stretch Receptors as Insecticide Targets</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2015-05-06</date><risdate>2015</risdate><volume>86</volume><issue>3</issue><spage>665</spage><epage>671</epage><pages>665-671</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Defining the molecular targets of insecticides is crucial for assessing their selectivity and potential impact on environment and health. 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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acoustic Stimulation Action Potentials - drug effects Action Potentials - genetics Animals Animals, Genetically Modified Arthropod Antennae - cytology Behavior CHO Cells Cricetulus Drosophila Drosophila Proteins - drug effects Drosophila Proteins - genetics Drosophila Proteins - metabolism Evacuations & rescues Experiments Gravity Sensing - drug effects Gravity Sensing - genetics Insects Ion Channels - drug effects Ion Channels - genetics Ion Channels - metabolism Larva Mechanoreceptors - drug effects Mechanoreceptors - physiology Movement - drug effects Neurons - drug effects Pesticides - pharmacology Proteins Quinazolinones - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Transient Receptor Potential Channels - drug effects Transient Receptor Potential Channels - genetics Triazines - pharmacology |
| title | TRP Channels in Insect Stretch Receptors as Insecticide Targets |
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