Simplified antibiotic regimens compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with clinical signs of possible serious bacterial infection when referral is not possible: a randomised, open-label, equivalence trial

Summary Background WHO recommends hospital-based treatment for young infants aged 0–59 days with clinical signs of possible serious bacterial infection, but most families in resource-poor settings cannot accept referral. We aimed to assess whether use of simplified antibiotic regimens to treat young...

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Veröffentlicht in:	The Lancet (British edition) 2015-05, Vol.385 (9979), p.1767-1776
Hauptverfasser:	Tshefu, Antoinette, PhD, Lokangaka, Adrien, MD, Ngaima, Serge, MD, Engmann, Cyril, MB BS, Esamai, Fabian, Prof, Gisore, Peter, MMed [Ped], Ayede, Adejumoke Idowu, MB BS, Falade, Adegoke Gbadegesin, MD, Adejuyigbe, Ebunoluwa A, Prof, Anyabolu, Chineme Henry, FWACP, Wammanda, Robinson D, Prof, Ejembi, Clara L, FNMCP, Ogala, William N, Prof, Gram, Lu, MSc, Cousens, Simon, DipMathStat
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amoxicillin - therapeutic use Anorexia - etiology Anti-Bacterial Agents - therapeutic use Antibiotics Babies Bacterial diseases Bacterial infections Bacterial Infections - complications Bacterial Infections - drug therapy Democratic Republic of the Congo Drug therapy Female Fever - etiology Gentamicins - therapeutic use Health facilities Humans Infant Infant, Newborn Infants Injections, Intramuscular Internal Medicine Kenya Lethargy - etiology Male Medical personnel Neonates Nigeria Penicillin G Procaine - therapeutic use Referral and Consultation Rural areas Single-Blind Method Therapeutic Equivalency Treatment Outcome
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