Immunologic characterization of 3 murine regimens of allergen-specific immunotherapy

Background Allergen-specific immunotherapy (ASIT) is used to treat the symptoms of immediate type I hypersensitivity. The mechanisms driving establishment of allergen tolerance are not yet fully understood. Objective The goal of this study was to develop and immunologically characterize 3 murine mod...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-05, Vol.135 (5), p.1341-1351.e7
Hauptverfasser:	Fox, Ellen Mueller, PhD, Torrero, Marina N., PhD, Evans, Holly, BS, Mitre, Edward, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	allergen-specific immunotherapy Allergens - administration & dosage Allergens - immunology Allergies Allergy and Immunology Anaphylaxis - immunology Animals basophils Basophils - immunology Basophils - metabolism Cytokines - biosynthesis Desensitization, Immunologic Disease Models, Animal Drinking water Drug dosages Female Flow cytometry Genotype & phenotype Hypersensitivity, Immediate - chemically induced Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - therapy Immunoglobulin Isotypes - blood Immunoglobulin Isotypes - immunology Immunomodulation Immunotherapy Laboratories mast cells Mice mouse models Ovalbumin - adverse effects Rodents Spleen - cytology Spleen - immunology Spleen - metabolism Studies T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Type I hypersensitivity
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