Phosphorylation of Ser-204 and Tyr-405 in human malonyl-CoA decarboxylase expressed in silkworm Bombyx mori regulates catalytic decarboxylase activity

Decarboxylation of malonyl-CoA to acetyl-CoA by malonyl-CoA decarboxylase (MCD; EC 4.1.1.9) is a vital catalytic reaction of lipid metabolism. While it is established that phosphorylation of MCD modulates the enzymatic activity, the specific phosphorylation sites associated with the catalytic functi...

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Veröffentlicht in:	Applied microbiology and biotechnology 2015-11, Vol.99 (21), p.8977-8986
Hauptverfasser:	Hwang, In-Wook, Makishima, Yu, Suzuki, Tomohiro, Kato, Tatsuya, Park, Sungjo, Terzic, Andre, Chung, Shin-kyo, Park, Enoch Y
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl coenzyme A Acetyl Coenzyme A - metabolism active sites Amino Acid Sequence Analysis Animals Baculoviridae Bioinformatics Biomedical and Life Sciences Biotechnologically Relevant Enzymes and Proteins Biotechnology Biotransformation Bombyx - genetics Bombyx - metabolism Bombyx mori Bombyx mori NPV Bombyx mori nucleopolyhedrovirus Carboxy-Lyases - genetics Carboxy-Lyases - metabolism Catalysis catalytic activity Chitinase Decarboxylases decarboxylation DNA Mutational Analysis E coli Enzymatic activity enzyme activity Enzymes Fatty acids Gene Expression Gene mutations Genetic Vectors Humans Influence Kinases Kinetics Laboratories Life Sciences lipid metabolism Lipids malonyl coenzyme A Malonyl Coenzyme A - metabolism Metabolism Microbial Genetics and Genomics Microbiology Mitochondria Models, Molecular Molecular Sequence Data Mutagenesis Mutation Oxidation Phosphorylation Point Mutation Post-translational modification Protein Conformation Protein Processing, Post-Translational Proteins proteomics Recombinant Proteins - genetics Recombinant Proteins - metabolism silkworms Studies Viruses
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