Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3

ABSTRACT Temporal lobe epilepsy (TLE) is a common type of epilepsy with hippocampus as the usual site of origin. The CA3 subfield of hippocampus is reported to have a low epileptic threshold and hence initiates the disorder in patients with TLE. This study computationally investigates how impaired d...

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Veröffentlicht in:	Hippocampus 2015-11, Vol.25 (11), p.1336-1350
Hauptverfasser:	Sanjay, M., Neymotin, Samuel A., Krothapalli, Srinivasa B.
Format:	Artikel
Sprache:	eng
Schlagworte:	basket cells CA3 Region, Hippocampal - physiology Dendrites - physiology depolarization block Epilepsy, Temporal Lobe - physiopathology hippocampus Humans ictal activity Neural Inhibition - physiology Neural Networks (Computer) Neuronal Plasticity - physiology oscillations Pyramidal Cells - physiology temporal lobe epilepsy
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