Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector
Highlights • A novel Sendai virus-based vector platform for vaccine developments. • Genome replication deficiency of the vector as contributing factor to safety. • Delivery and display of encoded antigens by two distinct ways. • Induction of a broad humoral response including neutralizing antibodies...
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| Veröffentlicht in: | Vaccine 2013-08, Vol.31 (37), p.3888-3893 |
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| container_issue | 37 |
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| container_title | Vaccine |
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| creator | Wiegand, Marian Gori-Savellini, Gianni Martorelli, Barbara Bossow, Sascha Neubert, Wolfgang J Cusi, Maria Grazia |
| description | Highlights • A novel Sendai virus-based vector platform for vaccine developments. • Genome replication deficiency of the vector as contributing factor to safety. • Delivery and display of encoded antigens by two distinct ways. • Induction of a broad humoral response including neutralizing antibodies and IgA. • Induction of strong specific cellular immune response including cytokine response. |
| doi_str_mv | 10.1016/j.vaccine.2013.06.053 |
| format | Article |
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Gori-Savellini, Gianni ; Martorelli, Barbara ; Bossow, Sascha ; Neubert, Wolfgang J ; Cusi, Maria Grazia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-4d77be35453cca322e30672f2baa5854dcc0270fc7222da8edce1fac7b5d1dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Allergy and Immunology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Neutralizing - blood</topic><topic>antigens</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>cell-mediated immunity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>genes</topic><topic>Genetic Vectors</topic><topic>Genome, Viral</topic><topic>Genomes</topic><topic>HN Protein - genetics</topic><topic>Human parainfluenza virus 3</topic><topic>Human respiratory syncytial virus</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity, Humoral</topic><topic>Immunization</topic><topic>lungs</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mucosal</topic><topic>neutralizing antibodies</topic><topic>Parainfluenza virus</topic><topic>Parainfluenza Virus 3, Human - genetics</topic><topic>Parainfluenza Virus 3, Human - immunology</topic><topic>Parainfluenza Virus 3, Human - pathogenicity</topic><topic>pathogens</topic><topic>Proteins</topic><topic>Replication-deficient vector</topic><topic>Respiratory diseases</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Vaccines - genetics</topic><topic>Respiratory Syncytial Virus Vaccines - immunology</topic><topic>Respiratory Syncytial Virus, Human - genetics</topic><topic>Respiratory Syncytial Virus, Human - pathogenicity</topic><topic>Sendai virus</topic><topic>Sendai virus - genetics</topic><topic>T-Lymphocytes - immunology</topic><topic>transcription (genetics)</topic><topic>Vaccine</topic><topic>vaccine development</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Vaccines, Synthetic - pharmacology</topic><topic>Viral Fusion Proteins - genetics</topic><topic>Virology</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiegand, Marian</creatorcontrib><creatorcontrib>Gori-Savellini, Gianni</creatorcontrib><creatorcontrib>Martorelli, Barbara</creatorcontrib><creatorcontrib>Bossow, Sascha</creatorcontrib><creatorcontrib>Neubert, Wolfgang J</creatorcontrib><creatorcontrib>Cusi, Maria Grazia</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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| ispartof | Vaccine, 2013-08, Vol.31 (37), p.3888-3893 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Allergy and Immunology Animal models Animals Antibodies, Neutralizing - blood antigens Applied microbiology Biological and medical sciences cell-mediated immunity Female Fundamental and applied biological sciences. Psychology Gene expression genes Genetic Vectors Genome, Viral Genomes HN Protein - genetics Human parainfluenza virus 3 Human respiratory syncytial virus Immune system Immunity Immunity, Humoral Immunization lungs Mice Mice, Inbred BALB C Microbiology Miscellaneous Mucosal neutralizing antibodies Parainfluenza virus Parainfluenza Virus 3, Human - genetics Parainfluenza Virus 3, Human - immunology Parainfluenza Virus 3, Human - pathogenicity pathogens Proteins Replication-deficient vector Respiratory diseases Respiratory syncytial virus Respiratory Syncytial Virus Vaccines - genetics Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - pathogenicity Sendai virus Sendai virus - genetics T-Lymphocytes - immunology transcription (genetics) Vaccine vaccine development Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology Viral Fusion Proteins - genetics Virology Virus Replication Viruses |
| title | Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector |
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