Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector

Highlights • A novel Sendai virus-based vector platform for vaccine developments. • Genome replication deficiency of the vector as contributing factor to safety. • Delivery and display of encoded antigens by two distinct ways. • Induction of a broad humoral response including neutralizing antibodies...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (37), p.3888-3893
Hauptverfasser:	Wiegand, Marian, Gori-Savellini, Gianni, Martorelli, Barbara, Bossow, Sascha, Neubert, Wolfgang J, Cusi, Maria Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Animals Antibodies, Neutralizing - blood antigens Applied microbiology Biological and medical sciences cell-mediated immunity Female Fundamental and applied biological sciences. Psychology Gene expression genes Genetic Vectors Genome, Viral Genomes HN Protein - genetics Human parainfluenza virus 3 Human respiratory syncytial virus Immune system Immunity Immunity, Humoral Immunization lungs Mice Mice, Inbred BALB C Microbiology Miscellaneous Mucosal neutralizing antibodies Parainfluenza virus Parainfluenza Virus 3, Human - genetics Parainfluenza Virus 3, Human - immunology Parainfluenza Virus 3, Human - pathogenicity pathogens Proteins Replication-deficient vector Respiratory diseases Respiratory syncytial virus Respiratory Syncytial Virus Vaccines - genetics Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - pathogenicity Sendai virus Sendai virus - genetics T-Lymphocytes - immunology transcription (genetics) Vaccine vaccine development Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology Viral Fusion Proteins - genetics Virology Virus Replication Viruses
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Beschreibung
Zusammenfassung:	Highlights • A novel Sendai virus-based vector platform for vaccine developments. • Genome replication deficiency of the vector as contributing factor to safety. • Delivery and display of encoded antigens by two distinct ways. • Induction of a broad humoral response including neutralizing antibodies and IgA. • Induction of strong specific cellular immune response including cytokine response.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.06.053