Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells

Lymphangiogenesis is essential in embryonic development but is rare in adults. It occurs, however, in many disease conditions including cancers. Vascular endothelial growth factor‐C/D (VEGF‐C/D) and VEGF receptor‐3 (Vegfr3) play a critical role in the regulation of lymphangiogenesis. We investigated...

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Veröffentlicht in:	The Journal of pathology 2015-11, Vol.237 (3), p.307-318
Hauptverfasser:	Qin, Ting-Ting, Xu, Guo-Ce, Qi, Jian-Wei, Yang, Gui-Li, Zhang, Kun, Liu, Hai-Lin, Xu, Li-Xia, Xiang, Rong, Xiao, Guozhi, Cao, Huiling, Wei, Yuquan, Zhang, Qiang-Zhe, Li, Lu-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cell Proliferation Cells, Cultured Dose-Response Relationship, Drug DR3 Endothelial Cells - drug effects Endothelial Cells - metabolism Injections, Intraperitoneal Lymph - metabolism lymphangiogenesis Lymphangiogenesis - drug effects lymphatic endothelial cell Lymphatic Vessels - cytology Lymphatic Vessels - drug effects Lymphatic Vessels - metabolism Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic NF-kappa B - metabolism Receptors, Tumor Necrosis Factor, Member 25 - genetics Receptors, Tumor Necrosis Factor, Member 25 - metabolism Recombinant Proteins - administration & dosage RNA Interference Signal Transduction Time Factors Tnfsf15 Transfection Tumor Necrosis Factor Ligand Superfamily Member 15 - administration & dosage Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Up-Regulation Vascular Endothelial Growth Factor C - metabolism Vascular Endothelial Growth Factor Receptor-3 - metabolism Vegfr3
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