Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease

IMPORTANCE: Alzheimer disease (AD) is the most common neurodegenerative disorder and lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of nerve growth factor (NGF) gene therapy in AD, the first effort at gene delivery in an adult neurodegenerative disorder. This pro...

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Veröffentlicht in:	JAMA neurology 2015-10, Vol.72 (10), p.1139-1147
Hauptverfasser:	Tuszynski, Mark H, Yang, Jennifer H, Barba, David, U, Hoi-Sang, Bakay, Roy A. E, Pay, Mary M, Masliah, Eliezer, Conner, James M, Kobalka, Peter, Roy, Subhojit, Nagahara, Alan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Alzheimer Disease - therapy Autopsy Brain - drug effects Brain - metabolism Female Gene Transfer Techniques Genetic Therapy Humans Male Middle Aged Nerve Degeneration - metabolism Nerve Growth Factor - therapeutic use Neurons - drug effects Neurons - metabolism
Online-Zugang:	Volltext
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