Juxtapositions between the somatostatinergic and growth hormone-releasing hormone (GHRH) neurons in the human hypothalamus
Highlights • The majority of the GHRH perikarya received contacting somatostatinergic axonal varicosities in the human hypothalamus. • These juxtapositions may represent the morphological substrate of the somatostatin-influenced GHRH secretion in humans. • In contrast, GHRH fibers commonly avoided t...
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| Veröffentlicht in: | Neuroscience 2015-06, Vol.297, p.205-210 |
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| creator | Proudan, N Peroski, M Grignol, G Merchenthaler, I Dudas, B |
| description | Highlights • The majority of the GHRH perikarya received contacting somatostatinergic axonal varicosities in the human hypothalamus. • These juxtapositions may represent the morphological substrate of the somatostatin-influenced GHRH secretion in humans. • In contrast, GHRH fibers commonly avoided the close vicinity of the somatostatinergic perikarya. • This phenomenon indicates that GHRH does not have significant direct influence on the hypothalamic somatostatin secretion. • GHRH may regulate somatostatin release by either hormonal route or indirectly, via other neurotransmitter systems. |
| doi_str_mv | 10.1016/j.neuroscience.2015.03.054 |
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| ispartof | Neuroscience, 2015-06, Vol.297, p.205-210 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged, 80 and over Female GHRH growth Growth Hormone-Releasing Hormone - metabolism Humans hypothalamus Hypothalamus - cytology Male Neuroeffector Junction - metabolism Neurology Neurons - metabolism somatostatin Somatostatin - metabolism |
| title | Juxtapositions between the somatostatinergic and growth hormone-releasing hormone (GHRH) neurons in the human hypothalamus |
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